fra
168
frataxin-like protein, required for the biosynthesis of iron-sulfur clusters, intracellular carrier to provide iron for the ferrochelatase HemH
locus
BSU_05750
Molecular weight
14.28 kDa
pI
5.38
function
intracellular iron channeling, biosynthesis of iron-sulfur clusters
product
frataxin-like protein
essential
no
synonyms
fra, ydhG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5646 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
621,847 622,218
Phenotypes of a mutant
severe growth phenotype associated with a broadly disturbed iron homeostasis [Pubmed|21744456]
The protein
Catalyzed reaction/ biological activity
transfers iron onto the B. subtilis SUF system ([protein|C0C30D2A6D3DF7A66063010044D370BD36D27DBF|sufU]-[protein|88ACE6B79534338F7C72F107B35A0B2384007088|sufS]) for iron-sulfur cluster biosynthesis [Pubmed|21744456]
[wiki|Cofactors]
Fe(2+) is bound with high affinity [Pubmed|20087498]
Structure
[PDB|2OC6]
[AF|Q797E6]
Expression and Regulation
Operons
Biological materials
Mutant
GP4705 Δ[gene|188833286AD73DF7730954D47BD676D8137679E9|fra]::aphA3, available in [wiki|Jörg Stülke]'s lab
MGNA-C182 (ydhG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2180 NBRP B. subtilis, Japan]
BKE05750 ([gene|188833286AD73DF7730954D47BD676D8137679E9|fra]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE05750 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTGTTCCCTCCTAAAA, downstream forward: _UP4_TGAAGAAAAAGGCATAACAT
BKK05750 ([gene|188833286AD73DF7730954D47BD676D8137679E9|fra]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK05750 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTGTTCCCTCCTAAAA, downstream forward: _UP4_TGAAGAAAAAGGCATAACAT
References
Reviews
Original Publications
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Time of last update: 2025-04-17 04:47:57
Author of last update: Jstuelk