murP
168
N-acetyl muramic acid permease of the [wiki|phosphotransferase systems|phosphotransferase system], EIIBC of the [category|SW.1.2.2|PTS]
locus
BSU_01680
Molecular weight
47.44 kDa
pI
8.5
function
N-acetyl muramic acid uptake and phosphorylation
product
N-acetyl muramic acid [category|SW.1.2.2|PTS] permease, EIIBC component
essential
no
ec
2.7.1.69
synonyms
murP, ybbF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1264 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
189,790 191,157
The protein
Catalyzed reaction/ biological activity
transport and concomitant phosphorylation of N-acetyl muramic acid
Protein family
[category|SW.1.2.2|PTS] permease, sucrose family [Pubmed|10627040]
[wiki|Domains]
[wiki|PTS EIIB domain] type-1 (aa 8-90) (according to UniProt)
[wiki|PTS EIIC domain] type-1 (aa 116-455) (according to UniProt)
Structure
[AF|Q797S1]
Paralogous protein(s)
[protein|35E6C81BE481C3E57CF47B781580368C3AC15D83|bglP], [protein|531F132F7F6A878F1E1D56977B9898A14272349A|sacX], [protein|AE02C38397AA790E4B216BB6DBABFE907B984D05|sacP], [protein|BC568649A341B2E6341993EDA4BF52BDE18A3294|treP]
Expression and Regulation
Operons
genes
[gene|0B1F43F43A4DC1574A153DBFBAA5D0A1855F9B61|murQ]-[gene|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]-[gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]-[gene|DEACFD435DB01C4B3ADEF397BEE08E2E7C7FCC36|amiE]-[gene|A5D4BF262BD365DCEBA9358C8DB295E605DE4D84|nagZ]-[gene|005D37F34CA3D6891F7D8FF7A2AFA1CBCB556FFE|namZ]
description
[Pubmed|22383849]
regulation
expressed in late exponential and early stationary phase [Pubmed|20400549]
regulatory mechanism
[protein|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]: repression, [pubmed|30038046], in [regulon|protein:125872506C400CB6B3DAEA8B5130B064DFBA4494|murR regulon]
Biological materials
Mutant
MGNA-B950 (ybbF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1949 NBRP B. subtilis, Japan]
BKE01680 ([gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE01680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTAAAACCCCTCCCCTTC, downstream forward: _UP4_TAAATTGTTTCTGTTTTAGG
BKK01680 ([gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK01680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTAAAACCCCTCCCCTTC, downstream forward: _UP4_TAAATTGTTTCTGTTTTAGG
References
Reviews
Original Publications
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Time of last update: 2024-12-20 14:56:34
Author of last update: Jstuelk