menE
168
[metabolite|o-succinylbenzoate-CoA] ligase
locus
BSU_30790
Molecular weight
54.02 kDa
pI
5.47
function
biosynthesis of [metabolite|menaquinone]
product
[metabolite|o-succinylbenzoate-CoA] ligase
essential
yes
ec
6.2.1.26
synonyms
menE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0318 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,147,350 3,148,810
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
[metabolite|ATP] + [metabolite|2-succinylbenzoate] + [metabolite|CoA] --> [metabolite|AMP] + [metabolite|diphosphate] + [metabolite|2-succinylbenzoyl-CoA] [pubmed|39422507]
Protein family
[wiki|ATP-dependent AMP-binding enzyme family] (according to UniProt)
Structure
[PDB|5BUQ] [Pubmed|26276389]
[PDB|5X8F] (complex with AMP and product analog) [Pubmed|28559280]
[PDB|5X8G] (complex with product analog) [Pubmed|28559280]
[AF|P23971]
Modification
[protein|16412BAB04BBF9FD1C3653328923687874C81868|menE] is acetylated on Lys-471 by [protein|17C3F56CE859BCD7A282C144C46CC92D3506ABF6|acuA], acetylation results in inactivation of [protein|16412BAB04BBF9FD1C3653328923687874C81868|menE] [pubmed|39422507]
deacetylation is catalyzed by [protein|A0A6CB19191A251BB5600C18E039978A9A34933C|srtN] [pubmed|39422507]
Expression and Regulation
Operons
genes
[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|26577401], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
genes
[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
genes
[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]-[gene|E3283812B7EB374EAC8722ECCE28432DE24B7B4C|menD]-[gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]-[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163,8550504]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
References
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Time of last update: 2024-12-12 21:29:38
Author of last update: Jstuelk