menE

menE
168

o-succinylbenzoate-CoA ligase

locus
BSU_30790
Molecular weight
54.02 kDa
pI
5.47
Protein length
Gene length
function
biosynthesis of menaquinone
product
o-succinylbenzoate-CoA ligase
essential
yes
ec
6.2.1.26
synonyms
menE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0318 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,147,350  3,148,810
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP +  2-succinylbenzoate + CoA --> AMP + diphosphate + 2-succinylbenzoyl-CoA (according to UniProt)
Protein family
[wiki|ATP-dependent AMP-binding enzyme family] (according to UniProt)
Structure
[PDB|5BUQ] [Pubmed|26276389]
[PDB|5X8F] (complex with AMP and product analog) [Pubmed|28559280]
[PDB|5X8G] (complex with product analog) [Pubmed|28559280]
[AF|P23971]
Expression and Regulation
Operons
genes
[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|26577401], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
Open in new tab

[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]→[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]

2024-09-14 18:30:41

ghost

66

f713102ea371e169facc30be56e42c9ab38c7214

053267978C7E78ECFF8ECD5CCD1C20DAF5B47C53

genes
[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
Open in new tab

[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]→[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]

2024-09-25 07:54:05

ghost

86

c8390ec183bfac05f12ebb94a80cf07cf1992fec

43D6A4FCF35A0BD074DE7BBC94193C874185009D

genes
[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]-[gene|E3283812B7EB374EAC8722ECCE28432DE24B7B4C|menD]-[gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]-[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163,8550504]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
Open in new tab

[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]→[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]

2024-09-25 07:47:03

ghost

83

a92ddbfdf5b67e100c673490a9f20821b9a45d89

AF4C2B1155E6061073411DDF2040DB62495353C0

References
9387221,1629163,8550504,26276389,26577401,27933791,28559280

16412BAB04BBF9FD1C3653328923687874C81868

Page visits: 4586

Time of last update: 2024-10-08 19:45:24

Author of last update: Jstuelk