gabP
168
gamma-amino butyric acid permease and minor proline permease
locus
BSU_06310
Molecular weight
50.93 kDa
pI
9.45
function
utilization of gamma-amino butyric acid
product
gamma-amino butyric acid permease
essential
no
synonyms
gabP, nrg-21
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1113 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
685,155 686,564
Phenotypes of a mutant
defective in the utilization of gamma-amino butyrate [Pubmed|24142252]
The protein
Catalyzed reaction/ biological activity
uptake of gamma-amino butyrate [Pubmed|24142252]
minor transporter for proline (allows growth with proline in the absence of the major [wiki|transporters] [protein|B3DF99B747D0A7472E3878920BF3CE7CE954B0BE|putP] and [protein|6A1F759DAC09D364602460E5467E2761E97CE45C|opuE]) [Pubmed|24142252]
Protein family
[wiki|amino acid-polyamine-organocation (APC) superfamily] (according to UniProt)
Structure
[AF|P46349]
Paralogous protein(s)
[protein|219586A3F378DC38EA076FD39B99D41136BDE722|alaP], [protein|423AEC9D260BE53AD22851D999244B89BEB3E84D|hutM], [protein|8C4A8961B2514A8AD531AFB104B10C0797D02AC2|yvbW], [protein|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB], [protein|9BFB16C12B31ABD70BBB921BCB9E4201E3BDC92D|rocC], [protein|B46A8BCEC56E6252712E30F8BF8DA6B836FDE2F6|rocE], [protein|B6A920650919D5BBBD75CCA58C30A0D8ECE64DA3|ybgF], [protein|C7FEA1D9C7C96C39CEE83CE3F13D412DE6AFE10E|ydgF], [protein|CE4A49F5CCC2D36C5CE5AD7AE7F0A70F2D4F425C|aapA]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|1594BA83CED2DA9F86C1CE2A0DC6E1C9B665EACB|gabP]
description
[Pubmed|8951816]
regulation
expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|8951816]
regulatory mechanism
[protein|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA]: activation, [Pubmed|8951816], in [regulon|protein:857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA regulon]
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|8951816], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8951816], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
GP3608 (erm), available in [wiki|Jörg Stülke]'s lab
available in [wiki|Erhard Bremer]'s lab [Pubmed|24142252]
BKE06310 ([gene|1594BA83CED2DA9F86C1CE2A0DC6E1C9B665EACB|gabP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGTTACCTCCTTTTAA, downstream forward: _UP4_TAATGCTGATCAAATCCTAA
BKK06310 ([gene|1594BA83CED2DA9F86C1CE2A0DC6E1C9B665EACB|gabP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGTTACCTCCTTTTAA, downstream forward: _UP4_TAATGCTGATCAAATCCTAA
References
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Time of last update: 2024-12-30 13:10:46
Author of last update: MBenda