pcp
168
pyrrolidone-carboxylate peptidase
locus
BSU_02650
Molecular weight
23.63 kDa
pI
6.42
function
removal of the N-terminal pyroglutamyl group from peptides
product
pyrrolidone-carboxylate peptidase
essential
no
ec
3.4.11.8
synonyms
pcp
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2039 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
286,773 287,420
The protein
Catalyzed reaction/ biological activity
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro (according to UniProt)
Protein family
peptidase C15 family (single member, according to UniProt)
Structure
[PDB|1AUG] (from B. amyloliquefaciens, 72% identity) [pubmed|10196127]
[AF|P28618]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Biological materials
Mutant
BKE02650 ([gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTCCCATCTCCTTTTT, downstream forward: _UP4_CACTAAGCGGCCGCCGCTGT
BKK02650 ([gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTCCCATCTCCTTTTT, downstream forward: _UP4_CACTAAGCGGCCGCCGCTGT
References
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Time of last update: 2024-10-09 09:16:19
Author of last update: Melvin.boenninger