pcp

pcp
168

pyrrolidone-carboxylate peptidase

locus
BSU_02650
Molecular weight
23.63 kDa
pI
6.42
Protein length
Gene length
function
removal of the N-terminal pyroglutamyl group from peptides
product
pyrrolidone-carboxylate peptidase
essential
no
ec
3.4.11.8
synonyms
pcp

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2039 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
286,773  287,420
The protein
Catalyzed reaction/ biological activity
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro (according to UniProt)
Protein family
peptidase C15 family (single member, according to UniProt)
Structure
[PDB|1AUG] (from B. amyloliquefaciens, 72% identity) [pubmed|10196127]
[AF|P28618]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]
description
[pubmed|22383849]
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[gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]

2024-12-30 17:24:18

Jstuelk

56

1ca546c50f3cf8ebe2bff64e93e3630584f13a76

874C38826491FF89FB68CFFB6F3E15FECDF9344A

Biological materials
Mutant
BKE02650 ([gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02650 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTCTCCCATCTCCTTTTT,  downstream forward: _UP4_CACTAAGCGGCCGCCGCTGT
BKK02650 ([gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02650 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTCTCCCATCTCCTTTTT,  downstream forward: _UP4_CACTAAGCGGCCGCCGCTGT
References
1362573,1353026,10196127

13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA

Page visits: 1277

Time of last update: 2024-12-27 17:39:52

Author of last update: Melvin.boenninger