gltX
168
glutamyl-tRNA synthetase, universally conserved protein
locus
BSU_00920
Molecular weight
55.56 kDa
pI
5.02
function
translation
product
glutamyl-tRNA synthetase
essential
yes
ec
6.1.1.17
synonyms
gltX
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0008 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
111,047 112,498
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-glutamate + tRNAGlu --> AMP + diphosphate + L-glutamyl-tRNAGlu(according to UniProt)
Protein family
[wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|3AKZ] (complex with tRNA-Gln from ''Thermotoga maritima'', 38% identity, 62% similarity) [Pubmed|20882017]
[AF|P22250]
[wiki|Localization]
cytoplasm (according to UniProt)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|132E91DB8C81CD8C4F5160B2C068B74DA10AE224|gltX]-[gene|5B9D5DA130DC3654F386684156BDC350DD05DB60|cysE]-[gene|E5826A99769E2FE45959A9D623D6467A8DDDEB81|cysS]-[gene|031FDF8443A8A4D5B042B7591EBE2E6C74F07702|mrnC]-[gene|8CB595F84D00D1262EB13E6CF47BE6F00EDE16A5|yacO]-[gene|172652156ABFE72D5BAAC22729CE17CA947538B5|yacP]
description
[Pubmed|7510287]
regulation
expression transiently increases in the forespore [Pubmed|22848659]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: RNA switch, overlaps a transcription terminator upstream of [gene|5B9D5DA130DC3654F386684156BDC350DD05DB60|cysE], in [regulon|other_regulator:T-box|T-box]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7510287], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
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Time of last update: 2024-12-05 12:52:51
Author of last update: Melvin.boenninger