yvrA
168
[wiki|ABC transporter] ([metabolite|ATP] binding domain) for [metabolite|cobalamin]
locus
BSU_33160
Molecular weight
48.47 kDa
pI
5.01
function
uptake of [metabolite|cobalamin]
product
[wiki|ABC transporter] ([metabolite|ATP] binding domain)
essential
no
synonyms
yvrA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1865 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,401,141 3,402,469
The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
Structure
[PDB|4G1U] (from Yersinia pestis, N-terminal domain, aa 1 .. 255, 41% identity) [pubmed|23142986]
[AF|O34631]
Expression and Regulation
Operons
genes
[gene|C76265F521D9A153F28AC6BACD935CC20DEA5D9C|yvrC]-[gene|1DC4A3D7E93677B0EAD15F43C80E50FD98527EBC|yvrB]-[gene|128EBAE9C14C7BB75173DF912853A6FCE86ABCE4|yvrA]-[gene|468D9141EAC78556C9F6C564875F70EC43E60C1C|yvqK]
regulation
expression is decreased in the presence of cobalamin (vitamin B12) ([wiki|B12 riboswitch]) [Pubmed|14704351]
regulatory mechanism
B12 riboswitch: RNA switch, upon binding of B12 [Pubmed|14704351], in [regulon|other_regulator:B12 riboswitch|B12 riboswitch]
Biological materials
Mutant
MGNA-B043 (yvrA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1042 NBRP B. subtilis, Japan]
BKE33160 ([gene|128EBAE9C14C7BB75173DF912853A6FCE86ABCE4|yvrA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33160 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCCCGACAGCCCTTCTGCCT, downstream forward: _UP4_TAAGTCTGTAAAGGAGATTC
BKK33160 ([gene|128EBAE9C14C7BB75173DF912853A6FCE86ABCE4|yvrA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33160 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCCCGACAGCCCTTCTGCCT, downstream forward: _UP4_TAAGTCTGTAAAGGAGATTC
References
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Time of last update: 2025-01-25 22:07:23
Author of last update: Jstuelk