acuC
168
protein deacetylase for the control of [protein|6671E7D85E99D349679F0E9D825DC035D10FFD2E|acsA] activity
locus
BSU_29710
Molecular weight
42.83 kDa
pI
5.06
function
control of [protein|6671E7D85E99D349679F0E9D825DC035D10FFD2E|acsA] activity
product
[protein|6671E7D85E99D349679F0E9D825DC035D10FFD2E|acsA] deacetylase
essential
no
synonyms
acuC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0123 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,041,392 3,042,555
The protein
Catalyzed reaction/ biological activity
deacetylates (and thereby activates) [protein|6671E7D85E99D349679F0E9D825DC035D10FFD2E|acsA] (together with [protein|A0A6CB19191A251BB5600C18E039978A9A34933C|srtN]) [Pubmed|19136592]
Protein family
histone deacetylase family (single member, according to UniProt)
Structure
[PDB|1C3R] (from Aquifex aeolicus, 35% identity) [pubmed|10490031]
[AF|P39067]
Expression and Regulation
Operons
genes
[gene|17C3F56CE859BCD7A282C144C46CC92D3506ABF6|acuA]-[gene|FC9981CFB9D7EB8ACDA3032EC2F0538988F277AA|acuB]-[gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]
description
[Pubmed|7934817]
regulation
repressed by glucose (3.4-fold) ([protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]) [Pubmed|7913927,12850135]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|7913927], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7913927], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the mRNA is quite stable (half-life 5 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
Biological materials
Mutant
GP1209 (''[gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]''::''kan''), available in [wiki|Jörg Stülke]'s lab
GP1213 (''[gene|A0A6CB19191A251BB5600C18E039978A9A34933C|srtN]''::''cat'')(''[gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]''::''kan''), available in [wiki|Jörg Stülke]'s lab
1A887 ( ''acuC''::''spc''), [Pubmed|16855235], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A887&Search=1A887 BGSC]
BKE29710 ([gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCTCATAGCAGATCCCTTTG, downstream forward: _UP4_CAAAGAACAAAGTAAAAAAC
BKK29710 ([gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCTCATAGCAGATCCCTTTG, downstream forward: _UP4_CAAAGAACAAAGTAAAAAAC
References
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Time of last update: 2024-12-20 14:00:01
Author of last update: Melvin.boenninger