yidC2
168
Sec-independent membrane protein translocase, required for development of genetic competence
locus
BSU_23890
Molecular weight
30.60 kDa
pI
9.9
function
membrane insertion of proteins and protein secretion
product
Sec-independent membrane protein translocase
essential
no
synonyms
yidC2, yqjG, oxaAB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0706 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,483,904 2,484,731
Advertisement
The protein
Protein family
OXA1/ALB3/YidC family (with [protein|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1], according to UniProt) [Pubmed|20800571,21194367,15802250]
Structure
[PDB|3WO6] (from ''Bacillus halodurans'', 41% identity) [Pubmed|24739968]
[AF|P54544]
Paralogous protein(s)
[protein|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1], one of the two proteins has to be present for viability [Pubmed|17114254]
[wiki|Localization]
membrane [Pubmed|22864117]
Expression and Regulation
Operons
genes
[gene|C50AE06E8C959EB7176504C8E2BAD1A08E47C51A|mifM]-[gene|121A9543F5BC1CBE77D85A34099DE09F8AC63E9F|yidC2]
description
[Pubmed|22383849]
regulation
repressed by large amounts of [wiki|SpoIIIJ], induced by small amounts of [wiki|SpoIIIJ] ([protein|search|MifM]) [Pubmed|19779460]
regulatory mechanism
[protein|C50AE06E8C959EB7176504C8E2BAD1A08E47C51A|mifM]: attenuation, an mRNA hairpin of the yqjG transcript unfold upon translation arrest of [protein|C50AE06E8C959EB7176504C8E2BAD1A08E47C51A|mifM] at decreased [protein|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1] levels, in [regulon|protein:C50AE06E8C959EB7176504C8E2BAD1A08E47C51A|mifM regulon]
additional information
An antisense RNA is predicted for '[protein|search|mifM]' [PubMed|20525796]
Biological materials
Mutant
MGNA-C389 (yqjG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2387 NBRP B. subtilis, Japan]
BKE23890 ([gene|121A9543F5BC1CBE77D85A34099DE09F8AC63E9F|yidC2]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATTTTGTTCTCCTCCTTT, downstream forward: _UP4_TAAAAAAGCAACCCCGTGCA
BKK23890 ([gene|121A9543F5BC1CBE77D85A34099DE09F8AC63E9F|yidC2]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATTTTGTTCTCCTCCTTT, downstream forward: _UP4_TAAAAAAGCAACCCCGTGCA
References
Reviews
Original Publications
Page visits: 3882
Time of last update: 2024-09-09 16:00:53
Author of last update: Jstuelk