metA
168
homoserine O-succinyltransferase
locus
BSU_21910
Molecular weight
25.85 kDa
pI
6.41
function
biosynthesis of methionine
product
homoserine O-succinyltransferase
essential
no
ec
2.3.1.46
synonyms
metA, metB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1897 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,305,378 2,306,283
The protein
Catalyzed reaction/ biological activity
acetyl-CoA + L-homoserine --> CoA + O-acetyl-L-homoserine (according to UniProt)
Protein family
MetA family (single member, according to UniProt)
Structure
[PDB|2GHR] (from ''Bacillus cereus'', 60% identity, 77% similarity) [Pubmed|17546672]
[AF|P54167]
Expression and Regulation
Operons
genes
[gene|1217330ECD588E24E42FF9FED2A097CEF32785F3|metA]-[gene|7A606B8E952AE8CA4F9A62008BA4B156725BB5B5|ugtP]
description
[Pubmed|22383849]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
Biological materials
Mutant
BKE21910 ([gene|1217330ECD588E24E42FF9FED2A097CEF32785F3|metA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE21910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACGTGCCACCTCCATTAT, downstream forward: _UP4_TAATTTTTCTTTTTTTAGTG
BKK21910 ([gene|1217330ECD588E24E42FF9FED2A097CEF32785F3|metA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK21910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACGTGCCACCTCCATTAT, downstream forward: _UP4_TAATTTTTCTTTTTTTAGTG
References
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Time of last update: 2024-12-17 14:38:38
Author of last update: Melvin.boenninger