patB
168
cystathione-beta-lyase
locus
BSU_31440
Molecular weight
42.63 kDa
pI
5.44
function
biosynthesis of methionine
product
cystathione-beta-lyase
essential
no
ec
4.4.1.8
synonyms
patB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1168 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,228,778 3,229,941
The protein
Catalyzed reaction/ biological activity
H2O + L,L-cystathionine --> L-homocysteine + NH4+ + pyruvate (according to UniProt)
Protein family
[wiki|class-II pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
[wiki|Cofactors]
PLP (according to UniProt)
Structure
[PDB|3T32] (from ''B. anthracis'', 46% identity, 75% similarity)
[AF|Q08432]
Expression and Regulation
Operons
Biological materials
Mutant
1A952 ( ''patB''::''cat''), [Pubmed|15760717], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A952&Search=1A952 BGSC]
BKE31440 ([gene|11B54D438CDD2EAA4A87A6B99851A3B123EA4A1F|patB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTGTTACCCCCTCATG, downstream forward: _UP4_TAAATATAGCTGTAAACGCC
BKK31440 ([gene|11B54D438CDD2EAA4A87A6B99851A3B123EA4A1F|patB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTGTTACCCCCTCATG, downstream forward: _UP4_TAAATATAGCTGTAAACGCC
References
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Time of last update: 2025-03-17 11:50:18
Author of last update: Melvin.boenninger