lytH

lytH
168

differentiation-associated peptidoglycan hydrolase involved in endospore cortex maturation

locus
BSU_32340
Molecular weight
39.48 kDa
pI
6.89
Protein length
Gene length
function
endospore cortex maturation
product
peptidoglycan hydrolase
essential
no
synonyms
lytH, yunA, yutA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0739 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,321,455  3,322,435
The protein
Catalyzed reaction/ biological activity
cleaves the peptide bond between L-Ala (position 1 in the peptioglycan peptide) and D-Glu (position 2) [Pubmed|18266855]
Protein family
peptidase M23B family (single member, according to UniProt)
Structure
[PDB|3NYY] (from Ruminococcus gnavus, the C-terminal peptidase M23 domain, aa 178 ... 315, 46% identity)
[AF|O32130]
Expression and Regulation
Operons
genes
[gene|11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6|lytH]
description
[Pubmed|12813075]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|12813075]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|12813075], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
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[gene|11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6|lytH]

2024-09-17 20:52:36

ghost

59

1a84c1b186da1ad850397557ac1d1127e38e2843

3009CC9AFBB587E816A7A56514B6623579929A99

Biological materials
Mutant
MGNA-B579 (yunA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1578 NBRP B. subtilis, Japan]
BKE32340 ([gene|11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6|lytH]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32340 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACAAAATAATCTCCTTTCA,  downstream forward: _UP4_TAACAAAAAGCCGCCTCTTC
BKK32340 ([gene|11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6|lytH]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32340 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACAAAATAATCTCCTTTCA,  downstream forward: _UP4_TAACAAAAAGCCGCCTCTTC
References
Reviews
18266855,35638784
Original Publications
12813075

11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6

Page visits: 2429

Time of last update: 2024-10-01 04:22:09

Author of last update: Jstuelk