ykwC
168
beta-hydroxyacid dehydrogenase
locus
BSU_13960
Molecular weight
30.56 kDa
pI
5.11
function
unknown
product
beta-hydroxyacid dehydrogenase
essential
no
ec
1.1.-.-
synonyms
ykwC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2084 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,465,733 1,466,599
The protein
Protein family
HIBADH-related family (with [protein|9F8A63C585227D59C8A5CD4356E3F81EB5897131|yfjR], according to UniProt)
Structure
[PDB|3WS7] (from ''Pyrobaculum calidifontis '', 42% identity)
[AF|O34948]
Modification
phosphorylated on Ser-281 by [protein|23FF4A00C36EC1B7297F51A9EF3579B41F0B7EBA|prkC], dephosphorylated by [protein|84447F9A6644EA8A7593BB99B2B69D4377E670E2|prpC], phosphorylation abolishes the oxidoreductase activity of YkwC ''in vitro'' and ''in vivo'' [Pubmed|24390483]
Paralogous protein(s)
[protein|9F8A63C585227D59C8A5CD4356E3F81EB5897131|yfjR], (32%)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|1010B1028A9A5F234C33474C7BC23C9BD2ABF3C4|ykwC]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B333 (ykwC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1332 NBRP B. subtilis, Japan]
BKE13960 ([gene|1010B1028A9A5F234C33474C7BC23C9BD2ABF3C4|ykwC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13960 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGTCATTCCTCCCAGAT, downstream forward: _UP4_TAAAAAAAGATTGCCTGTAC
BKK13960 ([gene|1010B1028A9A5F234C33474C7BC23C9BD2ABF3C4|ykwC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13960 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGTCATTCCTCCCAGAT, downstream forward: _UP4_TAAAAAAAGATTGCCTGTAC
References
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Time of last update: 2024-12-31 04:36:16
Author of last update: Melvin.boenninger