secE
168
preprotein translocase subunit
locus
BSU_01000
Molecular weight
6.79 kDa
pI
10.47
function
protein secretion
product
preprotein translocase subunit
essential
yes
synonyms
secE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0690 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
117,532 117,711
Phenotypes of a mutant
essential [Pubmed|12682299] [Pubmed|7968510]
The protein
Protein family
SecE/SEC61-gamma family (single member, according to UniProt)
[wiki|Domains]
transmembrane protein with a single TM domain
Structure
[PDB|3DL8] (structure of the ([protein|5350DC618130E013757EE667B9AFC5F2EC68EC08|secY]-[protein|1007EA15FB7AF81A44400287DB68BCC497158ACF|secE]-[protein|D8851F453E5EF18D36F25834A8CB9C61EAF15E44|secG])-[protein|AD7CD451B4AE638A719C91780339784A7FF0F248|secA] complex) [Pubmed|18923516]
[AF|Q06799]
[wiki|Localization]
cell membrane (according to UniProt)
Additional information
B. subtilis secE complements the secretion phenotype of a cold sensitive E. coli secE mutant.
Expression and Regulation
Operons
genes
[gene|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]-[gene|BBD82B93D5E880AB7093ED53DDB149B0E0B3BAE4|rpmGB]-[gene|1007EA15FB7AF81A44400287DB68BCC497158ACF|secE]
description
[Pubmed|22383849]
regulation
repressed during logrithmic growth ([protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]) [Pubmed|7592498]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|7592498], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1898930], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
Reviews
Original Publications
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Time of last update: 2024-12-21 18:20:00
Author of last update: Jstuelk