groES
168
chaperonin, universally conserved protein
locus
BSU_06020
Molecular weight
10.04 kDa
pI
4.59
function
protein folding and re-folding
product
chaperonin
essential
yes
synonyms
groES, groS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0234 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
649,903 650,187
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Protein family
groES chaperonin family (single member, according to UniProt)
Structure
[PDB|1WE3] ([protein|8F3DEE8828CA6BAAAF6DB2DA4349EF7AA9DF89F8|groEL]-[protein|0D8B3F1F86FDBAE0F3B3651F456340F147B394AF|groES] complex from ''Thermus thermophilus'', 65% identity) [Pubmed|15296740]
[AF|P28599]
Modification
phosphorylated on Ser-36 [Pubmed|20509597]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|0D8B3F1F86FDBAE0F3B3651F456340F147B394AF|groES]-[gene|8F3DEE8828CA6BAAAF6DB2DA4349EF7AA9DF89F8|groEL]
description
[Pubmed|1350777]
regulation
induced by heat shock ([protein|search|HrcA]) [Pubmed|1350777,8576042]
regulatory mechanism
[protein|2E57DFB4162EF0CE759C1FC42C637E1B9E4B2F7E|hrcA]: repression, [Pubmed|8576042], in [regulon|protein:2E57DFB4162EF0CE759C1FC42C637E1B9E4B2F7E|hrcA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1350776], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
labs
[wiki|Wolfgang Schumann], Bayreuth University, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/schumann_research.htm Homepage]
References
Reviews
Original Publications
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Time of last update: 2024-12-28 23:28:55
Author of last update: Jstuelk