iseA
168
secreted inhibitor of cell wall endopeptidases, inhibits cell separation
locus
BSU_18380
Molecular weight
19.98 kDa
pI
10.18
function
protection against cell envelope stress
product
inhibitor of autolysins
essential
no
synonyms
iseA, yoeB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
2,002,637 2,003,182
The protein
Structure
[PDB|2RSX] [Pubmed|23091053]
[AF|O34841]
[wiki|Localization]
secreted [pubmed|34871030]
Expression and Regulation
Operons
genes
[gene|0CA55371306D4BD768CFA82027DCB4D581BCCB87|iseA]
description
[Pubmed|22383849]
regulation
induced by vancomycin [Pubmed|17483219]
regulatory mechanism
[protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]: repression, [Pubmed|17581128], in [regulon|protein:7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR regulon]
additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
Biological materials
Mutant
MGNA-B076 (yoeB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1075 NBRP B. subtilis, Japan]
BKE18380 ([gene|0CA55371306D4BD768CFA82027DCB4D581BCCB87|iseA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18380 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATCGCTCTCTCCTTCA, downstream forward: _UP4_TAAGAAAAACGCCCGGTATA
BKK18380 ([gene|0CA55371306D4BD768CFA82027DCB4D581BCCB87|iseA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18380 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATCGCTCTCTCCTTCA, downstream forward: _UP4_TAAGAAAAACGCCCGGTATA
References
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Time of last update: 2024-11-15 21:23:57
Author of last update: Jstuelk