pcrB
168
heptaprenylglyceryl phosphate synthase
locus
BSU_06600
Molecular weight
24.94 kDa
pI
4.2
function
unknown
product
heptaprenylglyceryl phosphate synthase
essential
no
synonyms
pcrB, yerE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1646 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
718,622 719,308
The protein
Catalyzed reaction/ biological activity
production of heptaprenylglyceryl phosphate from heptaprenyl diphosphate and glycerol-1-phosphate [Pubmed|23322418]
all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate --> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate (according to UniProt)
Protein family
GGGP/HepGP synthase family (single member, according to UniProt)
Structure
[PDB|1VIZ] [Pubmed|23322418]
[AF|O34790]
Expression and Regulation
Operons
genes
[gene|0BA7EC658F5C2397A90B68AC234D04966966561C|pcrB]-[gene|C73E52D214E24F21696973B19B0A44CE785D6FBA|pcrA]-[gene|03EFF93C1B0CE075AE068ECC4EDE9BE5D03C857E|ligA]-[gene|ADAE6B5C301959D90592A6F26DFE1690BF6F5552|yerH]
description
[Pubmed|9701819]
regulation
induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
Biological materials
Mutant
MGNA-A926 (yerE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/926 NBRP B. subtilis, Japan]
BKE06600 ([gene|0BA7EC658F5C2397A90B68AC234D04966966561C|pcrB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTCATACGTTCCTCCAT, downstream forward: _UP4_TAGTAAATTGTACGGATTTG
BKK06600 ([gene|0BA7EC658F5C2397A90B68AC234D04966966561C|pcrB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTCATACGTTCCTCCAT, downstream forward: _UP4_TAGTAAATTGTACGGATTTG
References
Page visits: 3721
Time of last update: 2024-12-26 06:00:06
Author of last update: Melvin.boenninger