murJ

murJ
168

lipid II flippase

locus
BSU_30050
Molecular weight
59.30 kDa
pI
10.09
Protein length
Gene length
function
export of lipid II
product
lipid II flippase
essential
no
synonyms
murJ, ytgP

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5841 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,073,531  3,075,165
Phenotypes of a mutant
an ''[gene|12DB5AF311932991B66716BBCD08DA2C45B43BB9|amj] [gene|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|murJ]'' double mutant is not viable [Pubmed|25918422]
a ''[gene|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM] [gene|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|murJ]'' double mutant is not viable (due to the lack of both lipid II flippases) [Pubmed|25918422]
mutants lacking [protein|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|murJ] produce long cells and chains of cells  [Pubmed|19648239]
The protein
Protein family
[wiki|Polysaccharide synthase family] (according to UniProt)
[wiki|MOP exporter family]
Structure
[PDB|5T77] (from ''Thermosipho africanus'', 20% identity) [Pubmed|28024149]
[AF|O34674]
Paralogous protein(s)
[protein|34A5CD28A3DBCB10B4E1C82E50143FA73B553919|ykvU], [protein|9633C40190B7D0EA264270FD44567C61A012AD15|spoVB], [protein|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|murJ]-[gene|69052B24B577ABA4B20E610F679154DC97EFD8DE|ytzG]
description
[Pubmed|22383849]
Open in new tab

[gene|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|murJ]→[gene|69052B24B577ABA4B20E610F679154DC97EFD8DE|ytzG]

2024-10-03 15:53:24

Jstuelk

87

83d4ff96c0f28ad4450fc83611d635576aa14340

E9E6693CCC530C8F6C0BB625C5B08E91736B92E3

Biological materials
Mutant
MGNA-A012 (ytgP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/12 NBRP B. subtilis, Japan]
BKE30050 ([gene|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|murJ]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30050 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTTCTTCATCACCATT,  downstream forward: _UP4_TGATGAACTAGATATGATGA
BKK30050 ([gene|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|murJ]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30050 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTTCTTCATCACCATT,  downstream forward: _UP4_TGATGAACTAGATATGATGA
References
Reviews
26679002,28975672,33709487,37238589
Original Publications
19648239,25918422

0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E

Page visits: 3832

Time of last update: 2024-10-08 09:29:35

Author of last update: Jstuelk