pheS

pheS
168

phenylalanyl-tRNA synthetase (alpha subunit), universally conserved protein

locus
BSU_28640
Molecular weight
38.52 kDa
pI
5.08
Protein length
Gene length
function
translation
product
phenylalanyl-tRNA synthetase (alpha subunit)
essential
yes
ec
6.1.1.20
synonyms
pheS

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0016 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,929,438 2,930,472
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
ATP + L-phenylalanine + tRNAPhe --> AMP + diphosphate + H+ + L-phenylalanyl-tRNAPhe (according to UniProt)
Protein family
[wiki|Class-II aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|1PYS] (the [protein|0ABAEC20F55970C7C1EC5FFE197115E401BF03E8|pheS]-[protein|B255B87EB7A850D1C6B7930A3731DAD6AE0A107D|pheT] complex from ''Thermus thermophilus hb8 mutant'', 37% identity, 56% similarity) [Pubmed|7664121]
[AF|P17921]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|0ABAEC20F55970C7C1EC5FFE197115E401BF03E8|pheS]-[gene|B255B87EB7A850D1C6B7930A3731DAD6AE0A107D|pheT]
description
[Pubmed|2127701]
regulation
induced by phenylalanine limitation ([wiki|T-box]) [Pubmed|19258532]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: RNA switch, via tRNA controlled [wiki|RNA switch], in [regulon|other_regulator:T-box|T-box]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2127701], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|0ABAEC20F55970C7C1EC5FFE197115E401BF03E8|pheS]→[gene|B255B87EB7A850D1C6B7930A3731DAD6AE0A107D|pheT]

2024-05-21 15:04:29

Jstuelk

76

604c7f0822297bd3345163e5edd4c0c2a40eca4b

FF94A47A73789CF861E1FCC8CDB2858699A5CEE2

References
19258532,2127701,15378759,28516784,29794222,36815589

0ABAEC20F55970C7C1EC5FFE197115E401BF03E8

Page visits: 6116

Time of last update: 2024-05-23 09:04:28

Author of last update: Jstuelk