yueB
168
membrane protein, part of the type VII protein secretion system [protein|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[protein|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[protein|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[protein|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[protein|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC], receptor for phage SPPI
locus
BSU_31860
Molecular weight
119.77 kDa
pI
4.3
function
export of [protein|A177DF098115F85F23A1D42EFB07D294B515830F|yfjA], [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE], [protein|75B0239578C92D4F3B298CBB077635BF5567C590|yxiB], [protein|2401A4E3E5E683472C51AB2F31BC4F54F672F32A|ywqH]
product
part of the type VII protein secretion system, receptor for phage SPPI
essential
no
synonyms
yueB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1511 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,266,687 3,269,917
Phenotypes of a mutant
resistance to phage SPPI [Pubmed|15576783]
loss of secretion of [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE] [Pubmed|24798022]
The protein
Catalyzed reaction/ biological activity
receptor for phage SPP1 [Pubmed|15576783]
required for depolarization of the cytoplasmic membrane upon binding of phage SPP1 [Pubmed|22154073]
export of [protein|A177DF098115F85F23A1D42EFB07D294B515830F|yfjA], [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE], [protein|75B0239578C92D4F3B298CBB077635BF5567C590|yxiB], [protein|2401A4E3E5E683472C51AB2F31BC4F54F672F32A|ywqH] [Pubmed|39436054,24828531,23861817,11973144]
secretion and delivery of [wiki|LXG domain] toxins [pubmed|34280190]
Protein family
EsaA family (single member, according to UniProt)
Structure
[AF|O32101]
[wiki|Localization]
cell membrane [Pubmed|15576783,23861817], localizes preferentially to the cell poles [Pubmed|21705600]
exposed to the surface [Pubmed|16481324]
cytoplasm (homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]-[gene|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[gene|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[gene|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[gene|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[gene|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC]-[gene|B258CA26B0EC2310475FCCD67F1F196857FC0004|yueD]
description
[Pubmed|22383849]
regulation
expressed in the stationary phase [Pubmed|23861817]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]-P, [Pubmed|23861817], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|22383849], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-A649 (yueB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/649 NBRP B. subtilis, Japan]
BKE31860 ([gene|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCAAGCTTTTTCGTTGTT, downstream forward: _UP4_TGATCGCAGCATGGAAAAGG
BKK31860 ([gene|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCAAGCTTTTTCGTTGTT, downstream forward: _UP4_TGATCGCAGCATGGAAAAGG
References
Reviews
Original Publications
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Time of last update: 2024-12-20 23:20:08
Author of last update: Jstuelk