patA

patA
168

N-acetyl-L,L-diaminopimelate aminotransferase

locus
BSU_14000
Molecular weight
43.29 kDa
pI
6.01
Protein length
Gene length
function
biosynthesis of lysine and peptidoglycan
product
aminotransferase
essential
yes
ec
2.6.1.-
synonyms
patA, uat, dapX

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0436 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,471,857  1,473,038
Phenotypes of a mutant
essential [Pubmed|23109554]
The protein
Catalyzed reaction/ biological activity
N-acetyl-2-amino-6-ketopimelate - N-acetyl-L,L-2,6-diaminopimelate [Pubmed|24261876]
2-oxoglutarate + N-acetyl-LL-2,6-diaminoheptanedioate --> L-2-acetamido-6-oxoheptanedioate + L-glutamate (according to UniProt)
Protein family
[wiki|class-I pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
[wiki|Cofactors]
PLP
Structure
[PDB|1GDE] (from Pyrococcus sp., 42% identity) [pubmed|11134972]
[AF|P16524]
Paralogous protein(s)
[protein|62A9CD9AF72D0A48EC5ABC1585E2D8636D36D021|alaT], [protein|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]
description
[Pubmed|22383849]
Open in new tab

[gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]

2024-10-07 20:33:30

Jstuelk

93

d27ee90fad3b4de53c95464afaf6f3d4505abe25

9505633622CA13B8B55934B27F890FDCA84443A7

genes
[gene|5B177CBC33203B5B2DA841097CEB29B3A3C37C08|ykzT]-[gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]
description
[Pubmed|22383849]
Open in new tab

[gene|5B177CBC33203B5B2DA841097CEB29B3A3C37C08|ykzT]→[gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]

2024-09-28 13:16:22

Jstuelk

85

c72b939f5d592b5404c0c1f81947f1cf078b1557

BE5EADEA73973B44B6CF4E3B126BE3AE45CDF400

Biological materials
Mutant
BKE14000 ([gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14000 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAATTCATCACCTTAACA,  downstream forward: _UP4_AACAACGGCGTTTAAGCCGT
References
36815589,24261876,23109554,11134972,29280348,36069446

094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7

Page visits: 4559

Time of last update: 2024-10-13 19:39:14

Author of last update: Jstuelk