patA
168
N-acetyl-L,L-diaminopimelate aminotransferase
locus
BSU_14000
Molecular weight
43.29 kDa
pI
6.01
function
biosynthesis of lysine and peptidoglycan
product
aminotransferase
essential
yes
ec
2.6.1.-
synonyms
patA, uat, dapX
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0436 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,471,857 1,473,038
Phenotypes of a mutant
essential [Pubmed|23109554]
The protein
Catalyzed reaction/ biological activity
N-acetyl-2-amino-6-ketopimelate - N-acetyl-L,L-2,6-diaminopimelate [Pubmed|24261876]
2-oxoglutarate + N-acetyl-LL-2,6-diaminoheptanedioate --> L-2-acetamido-6-oxoheptanedioate + L-glutamate (according to UniProt)
Protein family
[wiki|class-I pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
[wiki|Cofactors]
PLP
Structure
[PDB|1GDE] (from Pyrococcus sp., 42% identity) [pubmed|11134972]
[AF|P16524]
Paralogous protein(s)
[protein|62A9CD9AF72D0A48EC5ABC1585E2D8636D36D021|alaT], [protein|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]
description
[Pubmed|22383849]
genes
[gene|5B177CBC33203B5B2DA841097CEB29B3A3C37C08|ykzT]-[gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE14000 ([gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATTCATCACCTTAACA, downstream forward: _UP4_AACAACGGCGTTTAAGCCGT
References
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Time of last update: 2024-12-05 23:30:31
Author of last update: Jstuelk