ywiE
168
minor cardiolipin synthetase, general stress protein, required for protection against paraquat stress
locus
BSU_37240
Molecular weight
58.08 kDa
pI
8.38
function
phospholipiid biosynthesis, protection against paraquat stress
product
minor cardiolipin synthetase
essential
no
ec
null
synonyms
ywiE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1502 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,821,570 3,823,072
The protein
Catalyzed reaction/ biological activity
2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) --> cardiolipin + glycerol (according to UniProt)
Protein family
phospholipase D family (with [protein|B63AAF0D3277FD776944A09D2546F3E48C8716AD|ywjE] and [protein|2079B210322F26EEC3CCF55611622FADDB1D1BC7|clsA], according to UniProt)
[wiki|Domains]
2 PLD phosphodiesterase domains (aa 237-264, aa 413-440) (according to UniProt)
Structure
[AF|P45860]
Paralogous protein(s)
[protein|2079B210322F26EEC3CCF55611622FADDB1D1BC7|clsA], [protein|B63AAF0D3277FD776944A09D2546F3E48C8716AD|ywjE]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|07752EC6940F43DEBD1E9313A2A195E35EDB9F69|ywiE]-[gene|D5A3C316BD4567A0155F70330E32ACDE18F063FE|ywjA]-[gene|685B58AD2A02A0B48B7D4AAAE046DE2CF8F77C58|ywjB]
description
[pubmed|22383849]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|26577401], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Biological materials
Mutant
MGNA-A553 (ywiE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/553 NBRP B. subtilis, Japan]
BKE37240 ([gene|07752EC6940F43DEBD1E9313A2A195E35EDB9F69|ywiE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37240 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCTGATTCTCTCCAATC, downstream forward: _UP4_TAAGAAAAAAGAAATCTGAT
BKK37240 ([gene|07752EC6940F43DEBD1E9313A2A195E35EDB9F69|ywiE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37240 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCTGATTCTCTCCAATC, downstream forward: _UP4_TAAGAAAAAAGAAATCTGAT
References
Page visits: 5376
Time of last update: 2024-12-22 08:24:14
Author of last update: Melvin.boenninger