mrpD

mrpD
168

H+ transporter subunit of the Na+/H+ antiporter, multiple resistance and pH homeostasis

locus
BSU_31630
Molecular weight
53.21 kDa
pI
9.49
Protein length
Gene length
function
sodium export
product
Na+/H+ antiporter subunit
essential
yes
synonyms
mrpD, yufD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0651 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,249,761  3,251,242
Phenotypes of a mutant
essential [Pubmed|12682299]
a ''[gene|051D9BCC0CB05E39ED5825BB9BA77B8228EA055D|mrpD]'' mutant is viable at pH7.4 and sodium concentrations below 80 mM [Pubmed|24139955]
The protein
Catalyzed reaction/ biological activity
H+ transporter subunit of the Na+/H+ antiporter [Pubmed|21236240]
Protein family
CPA3 antiporters (TC 2.A.63) subunit D family (single member, according to UniProt)
Structure
[PDB|4HE8] (from ''Thermus thermophilus'', 26% identity) [Pubmed|23417064]
[AF|O05229]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]-[gene|AAB15E7E3E3701AA3159370B85C151994244BA5B|mrpB]-[gene|D921139B18A665E9BB177C973FCF050A4BFFF97F|mrpC]-[gene|051D9BCC0CB05E39ED5825BB9BA77B8228EA055D|mrpD]-[gene|BF233467FAF95EEEE12A0D36C543DB357D8879EA|mrpE]-[gene|5CA2EA2D60FE4696903C16698C8329A20CBEBF72|mrpF]-[gene|B28796716C7E6C924F55176453DDBF9ADD0EF755|mrpG]
description
[Pubmed|9274030,10198001]
Open in new tab

[gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]→[gene|B28796716C7E6C924F55176453DDBF9ADD0EF755|mrpG]

2024-12-13 23:26:32

ghost

83

0833d14430981483bcfaa13a7a8e288e077b523f

4FC54E916920821D8932F58F7DE85186D61907A1

Biological materials
Mutant
MGNA-A609 (yufD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/609 NBRP B. subtilis, Japan]
References
Reviews
29218041
Original Publications
36815589,11004162,17693497,10198001,19389778,21236240,24095649,23417064,18408029

051D9BCC0CB05E39ED5825BB9BA77B8228EA055D

Page visits: 2885

Time of last update: 2024-12-21 03:42:14

Author of last update: Jstuelk