lnrJ
168
two-component sensor kinase, involved in resistance to linearmycin
locus
BSU_08290
Molecular weight
44.38 kDa
pI
6.39
function
involved in resistance to linearmycin
product
two-component sensor kinase
essential
no
synonyms
lnrJ, yfiJ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4585 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
903,811 905,013
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
5 transmembrane segments
[wiki|Histidine kinase domain] (aa 190-385) (according to UniProt)
Structure
[PDB|4GT8] (from Staphylococcus aureus, corresponds to aa 259 ... 390, 31% identity)
[AF|P94438]
Modification
autophosphorylation on a His residue
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B|lnrJ]-[gene|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]
description
[Pubmed|8973323]
Biological materials
Mutant
BKE08290 ([gene|03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B|lnrJ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGCTCATCACTCCCGATA, downstream forward: _UP4_GTGCAGCAAAAGGAGAGTTT
BKK08290 ([gene|03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B|lnrJ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGCTCATCACTCCCGATA, downstream forward: _UP4_GTGCAGCAAAAGGAGAGTTT
References
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Time of last update: 2024-12-30 08:48:45
Author of last update: Jstuelk