lytS
168
two-component sensor kinase, control of pyruvate utilization
locus
BSU_28930
Molecular weight
64.68 kDa
pI
8.24
function
control of pyruvate utilization
product
two-component sensor kinase
essential
no
synonyms
lytS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3275 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,956,486 2,958,267
Phenotypes of a mutant
no growth with pyruvate as the single carbon source [Pubmed|27422364]
The protein
Catalyzed reaction/ biological activity
ATP + [protein|search|L-histidine] --> ADP + [protein|search|N-phospho-L-histidine] (according to UniProt)
[wiki|Domains]
5 transmembrane regions
[wiki|GAF domain] (aa 238-363) (according to UniProt)
[wiki|Histidine kinase domain] (aa 363-580) (according to UniProt)
Structure
[AF|P94513]
Modification
autophosphorylation on a His residue
[wiki|Localization]
membrane (putative, due to presence of 5 membrane-spanning domains, according to Uniprot)
Expression and Regulation
Operons
genes
[gene|02FAD7D3A73CC0462D0116F4E5BA9505CBF7FCDD|lytS]-[gene|53BA24E91EEC797C95B8975C487F3C50CBBFA2E3|lytT]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-A015 (lytS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/15 NBRP B. subtilis, Japan]
BKE28930 ([gene|02FAD7D3A73CC0462D0116F4E5BA9505CBF7FCDD|lytS]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCATGTCACCTGTTCTT, downstream forward: _UP4_GAACATGCTCAGGGTGTTAA
BKK28930 ([gene|02FAD7D3A73CC0462D0116F4E5BA9505CBF7FCDD|lytS]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCATGTCACCTGTTCTT, downstream forward: _UP4_GAACATGCTCAGGGTGTTAA
References
Reviews
Original Publications
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Time of last update: 2024-12-20 14:55:35
Author of last update: Melvin.boenninger