csfB
168
anti-sigma factor, inhibitor of [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG] and of [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]
locus
BSU_00240
Molecular weight
7.30 kDa
pI
7.67
function
control of [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG] and [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE] activity
product
inhibitor of [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG] and [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]
essential
no
synonyms
csfB, gin, yaaM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5865 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
35,531 35,725
Phenotypes of a mutant
premature activation of [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG] [Pubmed|17921305]
The protein
Catalyzed reaction/ biological activity
inhibitor of [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG] and [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE] [pubmed|29526435,17921305,19497328]
[wiki|Cofactors]
Zn2+ [pubmed|29526435]
Structure
[PDB|5N7Y] [pubmed|29526435]
[AF|P37534]
[wiki|Localization]
forespore and mother cell [Pubmed|25835496]
Expression and Regulation
Operons
genes
[gene|01412FA454DDBA12622E3B32C433F8059123661B|csfB]
description
[Pubmed|22383849]
regulation
expressed after completion of forespore engulfment in the mother cell ([protein|search|SigK]) [Pubmed|25835496]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|16497325], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|25835496], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
Biological materials
Mutant
MGNA-B894 (yaaM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1893 NBRP B. subtilis, Japan]
BKE00240 ([gene|01412FA454DDBA12622E3B32C433F8059123661B|csfB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00240 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTCTCCACCTCCGTAC, downstream forward: _UP4_TAGACCTGAAAAGGTCTTTT
BKK00240 ([gene|01412FA454DDBA12622E3B32C433F8059123661B|csfB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00240 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTCTCCACCTCCGTAC, downstream forward: _UP4_TAGACCTGAAAAGGTCTTTT
References
Reviews
Original Publications
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Time of last update: 2024-12-18 09:09:14
Author of last update: Jstuelk