dapA
168
dihydrodipicolinate synthase
locus
BSU_16770
Molecular weight
30.89 kDa
pI
4.93
function
biosynthesis of lysine and peptidoglycan
product
dihydrodipicolinate synthase
essential
yes
ec
4.2.1.52
synonyms
dapA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0329 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,748,368 1,749,240
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
L-aspartate 4-semialdehyde + pyruvate --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (according to UniProt)
Protein family
DapA family (with [protein|3542BC20C11985B3CFAA4F930E8D794700ADFD2E|ycbC], according to UniProt)
Structure
[PDB|3CPR] (from ''Corynebacterium glutamicum'', 39% identity, 58% similarity) [Pubmed|18930704]
[AF|Q04796]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8098035], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]-[gene|4D93A13DB9DC55A49525BFF4FD589F4FF67D50E8|spoVFB]-[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|15699190,8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
References
Reviews
Original Publications
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Time of last update: 2024-10-13 09:01:22
Author of last update: Melvin.boenninger