dapA

dapA
168

dihydrodipicolinate synthase

locus
BSU_16770
Molecular weight
30.89 kDa
pI
4.93
Protein length
290 aaSequenceBlast
Gene length
873 bpSequenceBlast
function
biosynthesis of lysine and peptidoglycan
product
dihydrodipicolinate synthase
essential
yes
ec
4.2.1.52
synonyms
dapA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0329 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,748,368  1,749,240
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
L-aspartate 4-semialdehyde + pyruvate --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (according to UniProt)
Protein family
DapA family (with [protein|3542BC20C11985B3CFAA4F930E8D794700ADFD2E|ycbC], according to UniProt)
Structure
[PDB|3CPR] (from ''Corynebacterium glutamicum'', 39% identity, 58% similarity) [Pubmed|18930704]
[AF|Q04796]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8098035], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]→[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]

2024-12-04 00:00:00

ghost

90

26b99709bb2d46d49ca998bee33208e722bad3f7

5716FEABC6E16C3675FEA484CEBA95D8F93F13D1

genes
[gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]-[gene|4D93A13DB9DC55A49525BFF4FD589F4FF67D50E8|spoVFB]-[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|15699190,8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
Open in new tab

[gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]→[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]

2024-12-22 05:05:51

ghost

110

9f1758bf801d23548827e9d03f6ca9d0c2e6746d

C373CB045AB9232B86B60761B90C3510E98A06A8

References
Reviews
28271480
Original Publications
8345520,15699190,8098035

00B4CA4E25858A56F9D4E0ADEE2643F203FEC613

Page visits: 4009

Time of last update: 2024-12-22 05:04:37

Author of last update: Melvin.boenninger