facZ

facZ
168

Firmicute-associated coordinator of Z-rings, general stress protein

locus
BSU_29780
Molecular weight
15.60 kDa
pI
9.98
Protein length
Gene length
function
control of division site placement
product
coordinator of Z-rings
essential
no
synonyms
ytxG, csb40, facZ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4768 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,047,593  3,048,015
Phenotypes of a mutant
[category|SW.1.1.8|Cell division] and membrane defects [pubmed|38443581]
the mutant forms filaments [pubmed|39185233]
inactivation of ''[gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ]'' reduces sporulation efficiency to 39.6% that of wild type cells; aberrant membrane morphologies [Pubmed|26735940]
an [gene|B317D7E51824DD70EF84E4D5D7290D601BF4FAB6|ezrA] [gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ] double mutant has a severe growth defect [pubmed|39185233]
The protein
Protein family
UPF0478 family (single member, according to UniProt)
Structure
[AF|P40779]
[wiki|Localization]
membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ]-[gene|43BF293F735ED783D36F33AA4701D57F2AED6657|ytxH]-[gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]
description
[Pubmed|8733232]
regulation
induced by stress ([protein|search|SigB]) [Pubmed|8733232,11544224]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|8733232,11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|8733232], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
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[gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ]→[gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]

2024-10-10 15:26:20

ghost

91

a0db108502ded191eef0405d77d786ae7bc7abdc

623E0B035BA1319C480A20A9385612A917A73D50

Biological materials
Mutant
MGNA-B529 (ytxG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1528 NBRP B. subtilis, Japan]
BKE29780 ([gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29780 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTCAAACCTCCTTGCTG,  downstream forward: _UP4_TAAGAGAAAAAAATACTAAG
BKK29780 ([gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29780 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTCAAACCTCCTTGCTG,  downstream forward: _UP4_TAAGAGAAAAAAATACTAAG
References
11544224,8733232,18763711,26735940,38443581,39185233

00A42FDB559BE2647CD682180420A435E2E7035F

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Time of last update: 2024-10-10 19:12:24

Author of last update: Jstuelk