namZ
168
exo-β-N-acetylmuramidase
locus
BSU_01650
Molecular weight
45.87 kDa
pI
7.37
function
cell wall turnover and recycling
product
exo-β-N-acetylmuramidase
essential
no
synonyms
ybbC, yzbB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3876 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
185,194 186,438
The protein
Catalyzed reaction/ biological activity
exo-lytic cleavage of β-1,4-MurNAc entities from the non-reducing ends of peptidoglycan chains [pubmed|33684445]
hydrolysis of the peptidoglycan-derived disaccharide MurNAc-β-1,4-GlcNAc [pubmed|33684445]
Protein family
DUF1343 protein family [pubmed|33684445]
Structure
[PDB|4K05] (from Bacteroides fragilis, 43% identity)
[AF|P40407]
Expression and Regulation
Operons
genes
[gene|0B1F43F43A4DC1574A153DBFBAA5D0A1855F9B61|murQ]-[gene|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]-[gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]-[gene|DEACFD435DB01C4B3ADEF397BEE08E2E7C7FCC36|amiE]-[gene|A5D4BF262BD365DCEBA9358C8DB295E605DE4D84|nagZ]-[gene|005D37F34CA3D6891F7D8FF7A2AFA1CBCB556FFE|namZ]
description
[Pubmed|22383849]
regulation
expressed in late exponential and early stationary phase [Pubmed|20400549]
regulatory mechanism
[protein|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]: repression, [pubmed|30038046], in [regulon|protein:125872506C400CB6B3DAEA8B5130B064DFBA4494|murR regulon]
Biological materials
Mutant
BKE01650 ([gene|005D37F34CA3D6891F7D8FF7A2AFA1CBCB556FFE|namZ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE01650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGTTTTTCTCATGTGTCCCT, downstream forward: _UP4_TAGAACATAAGCATCGTATG
BKK01650 ([gene|005D37F34CA3D6891F7D8FF7A2AFA1CBCB556FFE|namZ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK01650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGTTTTTCTCATGTGTCCCT, downstream forward: _UP4_TAGAACATAAGCATCGTATG
References
Reviews
Original Publications
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Time of last update: 2024-12-30 03:52:06
Author of last update: Jstuelk