niaP
168
nicotinate transporter
locus
BSU_02950
Molecular weight
43.55 kDa
pI
9.5
function
uptake of niacin
product
nicotinate transporter
essential
no
synonyms
niaP, yceI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
317,725 318,927
Phenotypes of a mutant
more sensitive to nisin [Pubmed|23980836]
The protein
Protein family
[wiki|major facilitator superfamily] [Pubmed|18276644]
[wiki|Sugar transporter (TC 2.A.1.1) family] (according to UniProt)
[wiki|Domains]
10 membrane-spanning domains [Pubmed|18276644]
Structure
[PDB|4J05] (from ''P. indica'', 24% identity) [Pubmed|23542591]
[AF|O34691]
[wiki|Localization]
cell membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|0037A6808E75C2A2E207A7005EFDA71FCE90BAD8|niaP]
description
[Pubmed|22383849]
regulation
repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|18276644]
regulatory mechanism
[protein|510DE075EA964D22C42DEB171509F6CDA600A402|nadR]: repression, [Pubmed|18276644], in [regulon|protein:510DE075EA964D22C42DEB171509F6CDA600A402|nadR regulon]
Biological materials
Mutant
MGNA-C047 (yceI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2045 NBRP B. subtilis, Japan]
BKE02950 ([gene|0037A6808E75C2A2E207A7005EFDA71FCE90BAD8|niaP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02950 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCCAACACCTCTGATA, downstream forward: _UP4_TAGGAAAAGCACCTCTTAAA
BKK02950 ([gene|0037A6808E75C2A2E207A7005EFDA71FCE90BAD8|niaP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02950 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCCAACACCTCTGATA, downstream forward: _UP4_TAGGAAAAGCACCTCTTAAA
References
Reviews
Original Publications
Page visits: 2626
Time of last update: 2024-12-20 02:54:59
Author of last update: Melvin.boenninger