Category: Biofilm formation
[category|SW.4|4. Lifestyles]
[category|SW.4.1|4.1. Exponential and early post-exponential lifestyles]
[category|SW.4.1.2|4.1.2. Biofilm formation]
Name | Function |
[gene|6E6D17F51F9A82D38EA985AA7E09CB9530583802|ampS] | required for biofilm formation |
[gene|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA] | [wiki|biofilm formation], control of entry into [wiki|sporulation] via the [wiki|phosphorelay] |
[gene|40C1E81BAB04BD1CC98FC57DF25D27DBDFEB5A59|degQ] | regulation of exoenzyme synthesis |
[gene|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU] | regulation of degradative enzymes, [wiki|genetic competence], and other adaptive responses |
[gene|F6C4634BF871D9A01E27014FFED7527C54BF560D|epsA] | biofilm formation |
[gene|9B668909E1380B287ACE58561DCF45FC29184D8B|epsB] | biofilm formation |
[gene|5DB168A3D087AAEB003D7548A1A4356ABD07F712|epsC] | [category|SW.4.1.2|Biofilm formation], biosynthesis of UDP-N,N’-diacetylbacillosamine (with [protein|0D24AB8D446CFFBC6DEAD3C10D1FA59551545FE8|epsN] and [protein|40EA584CF77FFF7D7E4E74B414EC69ADE3A1585B|epsM]) |
[gene|223E979276F07D69D0DDAEE906023A8AB4F37F8E|epsD] | [wiki|biofilm formation] |
[gene|5D717F9F54693FD0AA8BC49E10348637858F88B9|epsE] | biofilm formation |
[gene|DB47BA2A5E3BED51DD8630E7D321C099D74B46CF|epsF] | [wiki|biofilm formation] |
[gene|C4D81976AAE888C4FE89A2EE5CF9A763CAD645FF|epsG] | biofilm formation |
[gene|BD843389F95BFB905071547AB243413A617F12A8|epsH] | synthesis of extracellular poly-N-acetylglucosamine |
[gene|6EBD8F7065B6C1996067F3120DD9CFEA91D3A444|epsI] | synthesis of extracellular poly-N-acetylglucosamine |
[gene|5272E807B6B98541EA155AA9748320E25767F096|epsJ] | synthesis of extracellular poly-N-acetylglucosamine |
[gene|66076952E512D53FC1FC62455A86ACFA21AE120D|epsK] | export of extracellular poly-N-acetylglucosamine |
[gene|D67665412B78B56752B460219445E4BEF52C3A1A|epsL] | biofilm formation |
[gene|40EA584CF77FFF7D7E4E74B414EC69ADE3A1585B|epsM] | [category|SW.4.1.2|Biofilm formation], biosynthesis of UDP-N,N’-diacetylbacillosamine (with [protein|5DB168A3D087AAEB003D7548A1A4356ABD07F712|epsC] and [protein|0D24AB8D446CFFBC6DEAD3C10D1FA59551545FE8|epsN]) |
[gene|0D24AB8D446CFFBC6DEAD3C10D1FA59551545FE8|epsN] | [category|SW.4.1.2|Biofilm formation], biosynthesis of UDP-N,N’-diacetylbacillosamine (with [protein|5DB168A3D087AAEB003D7548A1A4356ABD07F712|epsC] and [protein|40EA584CF77FFF7D7E4E74B414EC69ADE3A1585B|epsM]) |
[gene|52A47B49B1FB955EE7E3C316B57A2B4134F78480|epsO] | biofilm formation |
[gene|61893B4EB53FBBB9AD8BEEEFFCEFD0FC64544D6F|floT] | control of membrane fluidity |
[gene|4E7B9426CED372AA8A321A147116A3A589FBF20C|ftsH] | cell division, sporulation initiation |
[gene|314223775ECB9E969F4F898584FC4E5379E86C7F|galE] | galactose utilization |
[gene|A656321846B2E0D1F39B528E2D8B8E620CCD1148|kinC] | initiation of [wiki|sporulation] |
[gene|511E71BB1981758857854C8E9BF657287CE60C11|kinD] | initiation of [wiki|sporulation] |
[gene|FF61DC6CA162EEC191CDFC802E721FCBD32EC098|luxS] | methionine salvage |
[gene|C5C72925567927CC177CCAC5369F80D57B9FAB5F|mstX] | unknown |
[gene|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|ptkA] | protein phosphorylation |
[gene|CF73D86DB024575BE8F043A4C3996458F4262E46|ptpZ] | protein tyrosine dephosphorylation |
[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA] | control of biofilm formation |
[gene|CBC76FB453569550F14FE5015C05D45985C04979|remB] | regulation of [wiki|biofilm formation] |
[gene|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA] | control of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] activity, see [wiki|Targets of the Y complex] |
[gene|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF] | control of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] activity, see [wiki|Targets of the Y complex] |
[gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|rny] | RNA processing and degradation |
[gene|1C4F076D54F5A07AC351D722A403F249ED097555|sfp/1] | phosphopantetheinylates a serine residue in each of the seven peptidyl carrier protein domains of the first three subunits of surfactin synthetase (SrfAA-SrfAB-SrfAC) and AcpK |
[gene|1627167E7E9DBE444161A94D9F76317612C6401C|sfp/2] | phosphopantetheinylates a serine residue in each of the seven peptidyl carrier protein domains of the first three subunits of surfactin synthetase (SrfAA-SrfAB-SrfAC) and AcpK |
[gene|24D6A7DDCB25B99FBB670E9203F826596916B35C|sinI] | control of [wiki|biofilm formation] |
[gene|5A6FBAE6553343092862CB79E150F934978C32A9|sinR] | control of [wiki|biofilm formation] |
[gene|09B082BF39703F0D9A5980E643175DBD59F5B228|sipW] | [wiki|biofilm formation] |
[gene|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|slrA] | control of motility and biofilm formation |
[gene|920F91E748EE079FF864011D9052B073567C41E4|slrR] | regulation of initiation of [wiki|biofilm formation] and of autolysis |
[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA] | [metabolite|spermidine], polyamine biosynthesis |
[gene|CDD5C7B1CE58352D29BB86BCC2C3685D1D8898ED|speD] | [metabolite|spermidine], polyamine biosynthesis |
[gene|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A] | initiation of [wiki|sporulation] |
[gene|5D479874B43F521DB52EDC2C27CDE4967F22DE47|swrA] | control of [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU] activity |
[gene|0CEE58D799AF41634D161DBDF3D67EEFFF1C861E|swrAA/2] | essential for swarming differentiation on solid surfaces |
[gene|8C13E1EF5437DD8F9906643DEDCBB18DABE3B9E3|tapA] | [wiki|biofilm formation] |
[gene|BF97457E986656E4A9FE7A858F5BDF1759850D5C|tasA] | [wiki|biofilm formation] |
[gene|8DCA50478136628DD9E5D01E89609A686EED9F57|tkmA] | control of protein tyrosine phosphorylation |
[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg] | control of [wiki|biofilm formation] |
[gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP] | control of [protein|A656321846B2E0D1F39B528E2D8B8E620CCD1148|kinC] activity |
[gene|7821A09DADC6EAF589A882F05CC34BE900E06F2A|yloB] | accumulation of calcium in the spore |
[gene|154862E3FFA7CEBA5725BAD08E09D0E1C6B7F946|ymdB] | control of bistable gene expression |
[gene|752860E73AD1A72D6598F995B80F5B21A77A5CBD|yugO] | potassium exporter |
[gene|3D57D86B076CE5975C5A2516A6D26AEEFD143A55|yvcA] | complex colony development |
[gene|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|ywcC] | control of [gene|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|slrA] expression |
[gene|9A223AE85131511B7EA3A71EA57D87E8B167FA67|yxaB] | biofilm formation, survival of salt and ethanol stress |
[category|SW.4.1.2.1|4.1.2.1. Matrix polysaccharide synthesis]
Name | Function |
[gene|F6C4634BF871D9A01E27014FFED7527C54BF560D|epsA] | biofilm formation |
[gene|9B668909E1380B287ACE58561DCF45FC29184D8B|epsB] | biofilm formation |
[gene|5DB168A3D087AAEB003D7548A1A4356ABD07F712|epsC] | [category|SW.4.1.2|Biofilm formation], biosynthesis of UDP-N,N’-diacetylbacillosamine (with [protein|0D24AB8D446CFFBC6DEAD3C10D1FA59551545FE8|epsN] and [protein|40EA584CF77FFF7D7E4E74B414EC69ADE3A1585B|epsM]) |
[gene|223E979276F07D69D0DDAEE906023A8AB4F37F8E|epsD] | [wiki|biofilm formation] |
[gene|5D717F9F54693FD0AA8BC49E10348637858F88B9|epsE] | biofilm formation |
[gene|DB47BA2A5E3BED51DD8630E7D321C099D74B46CF|epsF] | [wiki|biofilm formation] |
[gene|C4D81976AAE888C4FE89A2EE5CF9A763CAD645FF|epsG] | biofilm formation |
[gene|BD843389F95BFB905071547AB243413A617F12A8|epsH] | synthesis of extracellular poly-N-acetylglucosamine |
[gene|6EBD8F7065B6C1996067F3120DD9CFEA91D3A444|epsI] | synthesis of extracellular poly-N-acetylglucosamine |
[gene|5272E807B6B98541EA155AA9748320E25767F096|epsJ] | synthesis of extracellular poly-N-acetylglucosamine |
[gene|66076952E512D53FC1FC62455A86ACFA21AE120D|epsK] | export of extracellular poly-N-acetylglucosamine |
[gene|D67665412B78B56752B460219445E4BEF52C3A1A|epsL] | biofilm formation |
[gene|40EA584CF77FFF7D7E4E74B414EC69ADE3A1585B|epsM] | [category|SW.4.1.2|Biofilm formation], biosynthesis of UDP-N,N’-diacetylbacillosamine (with [protein|5DB168A3D087AAEB003D7548A1A4356ABD07F712|epsC] and [protein|0D24AB8D446CFFBC6DEAD3C10D1FA59551545FE8|epsN]) |
[gene|0D24AB8D446CFFBC6DEAD3C10D1FA59551545FE8|epsN] | [category|SW.4.1.2|Biofilm formation], biosynthesis of UDP-N,N’-diacetylbacillosamine (with [protein|5DB168A3D087AAEB003D7548A1A4356ABD07F712|epsC] and [protein|40EA584CF77FFF7D7E4E74B414EC69ADE3A1585B|epsM]) |
[gene|52A47B49B1FB955EE7E3C316B57A2B4134F78480|epsO] | biofilm formation |
[gene|314223775ECB9E969F4F898584FC4E5379E86C7F|galE] | galactose utilization |
[category|SW.4.1.2.2|4.1.2.2. Amyloid protein synthesis, secretion and assembly]
Name | Function |
[gene|09B082BF39703F0D9A5980E643175DBD59F5B228|sipW] | [wiki|biofilm formation] |
[gene|8C13E1EF5437DD8F9906643DEDCBB18DABE3B9E3|tapA] | [wiki|biofilm formation] |
[gene|BF97457E986656E4A9FE7A858F5BDF1759850D5C|tasA] | [wiki|biofilm formation] |
[category|SW.4.1.2.3|4.1.2.3. Repellent surface layer]
Name | Function |
[gene|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA] | [wiki|biofilm formation], control of entry into [wiki|sporulation] via the [wiki|phosphorelay] |
[category|SW.4.1.2.4|4.1.2.4. Regulation]
Name | Function |
[gene|40C1E81BAB04BD1CC98FC57DF25D27DBDFEB5A59|degQ] | regulation of exoenzyme synthesis |
[gene|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU] | regulation of degradative enzymes, [wiki|genetic competence], and other adaptive responses |
[gene|4E7B9426CED372AA8A321A147116A3A589FBF20C|ftsH] | cell division, sporulation initiation |
[gene|A656321846B2E0D1F39B528E2D8B8E620CCD1148|kinC] | initiation of [wiki|sporulation] |
[gene|511E71BB1981758857854C8E9BF657287CE60C11|kinD] | initiation of [wiki|sporulation] |
[gene|C5C72925567927CC177CCAC5369F80D57B9FAB5F|mstX] | unknown |
[gene|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|ptkA] | protein phosphorylation |
[gene|CF73D86DB024575BE8F043A4C3996458F4262E46|ptpZ] | protein tyrosine dephosphorylation |
[gene|24D6A7DDCB25B99FBB670E9203F826596916B35C|sinI] | control of [wiki|biofilm formation] |
[gene|5A6FBAE6553343092862CB79E150F934978C32A9|sinR] | control of [wiki|biofilm formation] |
[gene|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|slrA] | control of motility and biofilm formation |
[gene|920F91E748EE079FF864011D9052B073567C41E4|slrR] | regulation of initiation of [wiki|biofilm formation] and of autolysis |
[gene|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A] | initiation of [wiki|sporulation] |
[gene|8DCA50478136628DD9E5D01E89609A686EED9F57|tkmA] | control of protein tyrosine phosphorylation |
[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg] | control of [wiki|biofilm formation] |
[gene|154862E3FFA7CEBA5725BAD08E09D0E1C6B7F946|ymdB] | control of bistable gene expression |
[gene|752860E73AD1A72D6598F995B80F5B21A77A5CBD|yugO] | potassium exporter |
[category|SW.4.1.2.5|4.1.2.5. Other proteins required for biofilm formation]
Name | Function |
[gene|6E6D17F51F9A82D38EA985AA7E09CB9530583802|ampS] | required for biofilm formation |
[gene|42C8D303AABFA2A9706295A0F90B0B49F854B0BF|dhbA] | biosynthesis of the siderophore bacillibactin |
[gene|1346D57F906EE5BD36F7FBFA1E4884EEBC8585FA|dhbB] | biosynthesis of the siderophore bacillibactin |
[gene|0D4D200095AD4F9B30179B9AF500306EDA61F5D1|dhbC] | biosynthesis of the siderophore bacillibactin |
[gene|61893B4EB53FBBB9AD8BEEEFFCEFD0FC64544D6F|floT] | control of membrane fluidity |
[gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA] | biosynthesis of phospholipids |
[gene|FF61DC6CA162EEC191CDFC802E721FCBD32EC098|luxS] | methionine salvage |
[gene|DDD40AEBBCBD3C19661A72B85912E266DBF267B3|menH] | biosynthesis of menaquinone |
[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA] | control of biofilm formation |
[gene|CBC76FB453569550F14FE5015C05D45985C04979|remB] | regulation of [wiki|biofilm formation] |
[gene|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA] | control of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] activity, see [wiki|Targets of the Y complex] |
[gene|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF] | control of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] activity, see [wiki|Targets of the Y complex] |
[gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|rny] | RNA processing and degradation |
[gene|003047E90159765F9F0E499FD760F95FFF4AC360|rqcH] | rescue of stalled ribosomes |
[gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC] | TCA cycle |
[gene|1C4F076D54F5A07AC351D722A403F249ED097555|sfp/1] | phosphopantetheinylates a serine residue in each of the seven peptidyl carrier protein domains of the first three subunits of surfactin synthetase (SrfAA-SrfAB-SrfAC) and AcpK |
[gene|1627167E7E9DBE444161A94D9F76317612C6401C|sfp/2] | phosphopantetheinylates a serine residue in each of the seven peptidyl carrier protein domains of the first three subunits of surfactin synthetase (SrfAA-SrfAB-SrfAC) and AcpK |
[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA] | [metabolite|spermidine], polyamine biosynthesis |
[gene|CDD5C7B1CE58352D29BB86BCC2C3685D1D8898ED|speD] | [metabolite|spermidine], polyamine biosynthesis |
[gene|5D479874B43F521DB52EDC2C27CDE4967F22DE47|swrA] | control of [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU] activity |
[gene|0CEE58D799AF41634D161DBDF3D67EEFFF1C861E|swrAA/2] | essential for swarming differentiation on solid surfaces |
[gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP] | control of [protein|A656321846B2E0D1F39B528E2D8B8E620CCD1148|kinC] activity |
[gene|3D57D86B076CE5975C5A2516A6D26AEEFD143A55|yvcA] | complex colony development |
[gene|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|ywcC] | control of [gene|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|slrA] expression |
[gene|9A223AE85131511B7EA3A71EA57D87E8B167FA67|yxaB] | biofilm formation, survival of salt and ethanol stress |
[category|SW.4.1.2.6|4.1.2.6. Other proteins required for efficient pellicle biofilm formation]
Name | Function |
[gene|6B3B222E56BF0C95A2371CA5208B5522B44D4689|cheA] | chemotactic signal modulator |
[gene|BE9373BEB682E5F8B0938AAA4ED9B723B357ABAE|cheD] | [wiki|motility and chemotaxis] |
[gene|56E391BD4C154A603FFD06CEC7BC5615AAC5AD04|cheV] | control of CheA activity |
[gene|2F0495C7EAB81BDB1F3181677C555537BD2A972F|cheY] | modulation of flagellar switch bias |
[gene|DC906ED8D787602B5796BAD8FD81F02C4BAC8D13|flgE] | movement and chemotaxis |
[gene|EB815705133E3318F655F6024B7D9BA587FD1DDA|fliF] | movement and chemotaxis |
[gene|E0BB77C8F1220E931D16A1FA6B75AE8907C76FDB|hag] | [wiki|motility and chemotaxis] |
[gene|B948B9D96CDC43A07B3FF90212E52230A0EF1905|hemAT] | movement towards oxygen |
[gene|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA] | [category|SW.4.1.1|Motility and chemotaxis] |
[gene|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD] | regulation of flagella, motility, chemotaxis and autolysis |
Description
Biofilms are the result of the multicellular lifestyle of B. subtilis. They are characterized by the formation of a matrix polysaccharide (poly-N-acetyl glucosamine as a major polysaccharide [pubmed|26078454]) and an amyloid-like protein, [protein|search|tasA]. Correction of [gene|search|sfp/2], [gene|search|epsC], [gene|search|swrA], [gene|search|swrAA/2], and [gene|search|degQ] as well as introduction of rapP from a plasmid present in NCIB3610 results in biofilm formation in B. subtilis 168 [pubmed|21278284].
Labs working on biofilm formation
[wiki|Roberto Grau]
[wiki|Daniel Kearns]
[wiki|Roberto Kolter]
[wiki|Akos T Kovacs]
[wiki|Oscar Kuipers]
[wiki|Beth Lazazzera]
[wiki|Richard Losick]
[wiki|Nicola Stanley-Wall]
important original publications
key reviews
Page visits:
Time of last update: 2024-10-04 11:25:20
Author of last update: Jstuelk