Category: Biosynthesis of cofactors

[category|SW.2|2. Metabolism]

[category|SW.2.6|2.6. Additional metabolic pathways]

[category|SW.2.6.2|2.6.2. Biosynthesis of cofactors]

[category|SW.2.6.2.1|2.6.2.1. Biosynthesis/ acquisition of biotin]

Name	Function
[gene\|68C86FED3575B864C576DFB73FE7B5BF83994D1F\|bioA]	biosynthesis of biotin
[gene\|5880617EB95FC0D19219A868D6D0A3D1D0D9C532\|bioB]	biosynthesis of biotin
[gene\|D9A71DAF949FB6C9C22C8361D83C5A0741184977\|bioD]	biosynthesis of biotin
[gene\|8B6A3E86A88928526D94FDA94B9C81ABF6E9ACFB\|bioF]	biosynthesis of biotin
[gene\|8FBC9A1AC108DC99E275D7A27C18C797D3CDB936\|bioI]	biosynthesis of biotin
[gene\|C40116089BAD3F9831F8C837DC4F2E045753ABDE\|bioW]	biosynthesis of biotin
[gene\|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D\|birA]	regulation of biotin synthesis, addition of biotin to proteins

[category|SW.2.6.2.2|2.6.2.2. Biosynthesis/ acquisition of riboflavin/ FAD]

Name	Function
[gene\|F07B7062C850106A95C15978E36DA500F8B089D6\|ribA]	riboflavin biosynthesis
[gene\|85E732993186528CF58FECFFE89C8F39D278F28D\|ribC]	FAD biosynthesis
[gene\|3DFCF7C5FE15C9A3E9E7E4B0DA8E926B85DBD180\|ribD]	riboflavin biosynthesis
[gene\|4E18BD4B084094EE4FBC8FE2AC95B14581D20C0F\|ribE]	riboflavin biosynthesis
[gene\|2A5DCBFAB51996F0DDEC964D5D178274AF86CE69\|ribH]	riboflavin biosynthesis
[gene\|8146A052E4E7844F781E7169C264EC927DEB7387\|ribT]	acetylation of [protein\|2A5DCBFAB51996F0DDEC964D5D178274AF86CE69\|ribH]
[gene\|651C370386E9FB45E3B98001800D342FEDB43E9A\|ribU]	riboflavin uptake
[gene\|D8AC0ECC57C6113D0CCA36FC38395EECBD00FF50\|ycsE]	dephosphorylation of the riboflavin precursor, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate
[gene\|29EFA7585D7B2FD3A2CDBE2F21AB6742980759B4\|yitU]	dephosphorylation of the riboflavin precursor, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate (minor activity)
[gene\|9730F7C18AC7CA68D144717851A0C261D9647E31\|ywtE]	dephosphorylation of the riboflavin precursor, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate (minor activity)

[category|SW.2.6.2.3|2.6.2.3. Biosynthesis/ acquisition of thiamine]

Name	Function
[gene\|EA9FCF84AE4FA80993566B62A9200D4B32AF5670\|dxs]	biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis
[gene\|47E47FB7D9C079DF603906694C4649A049814346\|tenA]	thiamine salvage
[gene\|CA6AAE8AC5B5EF01A911B035F8782579CD876C08\|tenI]	biosynthesis of thiamine
[gene\|51B5F268EE71DD28741A38F72E507B6E245D5494\|thiC]	biosynthesis of thiamine
[gene\|97EDB4ACD64C5FA2E6014ED133DF18F602FF58BB\|thiD]	biosynthesis of thiamine pyrophosphate (TPP)
[gene\|8FAEB6342E087BEDC16FDF5585B03B90ACFF8D11\|thiE]	biosynthesis of thiamine by 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate
[gene\|CCD3DDE9E52FCD4906735059CF30593BEB56FD1B\|thiF]	biosynthesis of thiamine
[gene\|B58B8F260E446E28BC2E3A9AA84EA771EC0A8634\|thiG]	biosynthesis of thiamine
[gene\|DE32F1DA1EA1164411E0605262381BD38A49656C\|thiL]	biosynthesis of thiamine
[gene\|9B82059498F72A67282DD54892EF02A305E3C674\|thiM]	biosynthesis of thiamine
[gene\|87B5C84B7EE10F60B545CCFEF6A527A546B80432\|thiO]	biosynthesis of thiamine
[gene\|95DA3F899037140F48B99E065C768356CE08FA94\|thiS]	biosynthesis of thiamine
[gene\|9685A380F95F1A73A693B53E4D35A1CB51043FEC\|thiT]	thiamine uptake
[gene\|57A953B5D71F3FD8269EAF2366B8E2C7A8C79483\|thiU]	thiamine uptake
[gene\|9AF27E4CE34B5C4036840A27D93B13213E3324DD\|thiV]	thiamine uptake
[gene\|EF69891D9CF0CE57367B38FB3C69DDE1B689FCB7\|thiW]	thiamine uptake
[gene\|236095EDE02EC9EA7768D9D30CED2345D3B7A1A9\|thiX]	thiamine uptake
[gene\|392921E3C53846236DF75D7585697969B11AF2F3\|ylmB]	thiamine salvage
[gene\|0ACE023DCD6A6BB5A1827D1D997BDFAC3B168C51\|yloS]	thiamine salvage

[category|SW.2.6.2.4|2.6.2.4. Biosynthesis of coenzyme A]

Name	Function
[gene\|151A61315ADAA7213502F15C0C0ED636A4C3EA7C\|aimA]	low affinity uptake of [metabolite\|serine], [metabolite\|glutamate], [metabolite\|asparagine], [metabolite\|glycine], [metabolite\|alanine], and [metabolite\|beta-alanine]
[gene\|219586A3F378DC38EA076FD39B99D41136BDE722\|alaP]	uptake of D- and L-alanine and of ß-alanine
[gene\|B3362449EF3C9D533090FBD7E7333A3CC5D902CB\|coaA]	biosynthesis of [metabolite\|coenzyme A]
[gene\|2B67C63442F28F6BCBA3BA6DE4B563C73E8DF16C\|coaBC]	biosynthesis of [metabolite\|coenzyme A]
[gene\|6DAAEF20B68139A732FDCDABD0C420A0C928D373\|coaD]	biosynthesis of [metabolite\|coenzyme A]
[gene\|E163A282560DB882B81E783E7E95E1960F4AE4D2\|coaE]	synthesis of [metabolite\|coenzyme A]
[gene\|9B8EAD4EDDA97526D4462F6F3205F81FECD039DE\|coaX]	biosynthesis of [metabolite\|coenzyme A]
[gene\|EC1CB2FD563EFDA391D13EB8ADFDC8C9734E9D57\|ilvC]	biosynthesis of branched-chain amino acids and [metabolite\|coenzyme A]
[gene\|A0001681244113B808757281C1B70C0C94F28A27\|panB]	biosynthesis of [metabolite\|coenzyme A]
[gene\|8BE55434677F4EC3D6766C7163496CB1B659F57F\|panC]	biosynthesis of [metabolite\|coenzyme A]
[gene\|EE712C1EC9E9C371847C83F7D75C189B276CD4B6\|panD]	biosynthesis of [metabolite\|coenzyme A]
[gene\|0F153803781C9AC8321FB14F926B645C45E53B00\|panE]	biosynthesis of [metabolite\|coenzyme A]
[gene\|60264E4BE76F5995A8317294D05FC27F8B34E09D\|panG]	biosynthesis of [metabolite\|coenzyme A]
[gene\|22215066A7BEA4E53189DE6639C19D1AD86DA7F4\|panU]	uptake of [metabolite\|pantothenate]

[category|SW.2.6.2.5|2.6.2.5. Biosynthesis of folate]

Name	Function
[gene\|B740E971204AC14BA456B8C93A86D4BDC29524FF\|dfrA]	biosynthesis of folate
[gene\|AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787\|folB]	biosynthesis of folate
[gene\|80502F76F076C08CCE702F25095C06D14CD8154A\|folC]	biosynthesis of folate
[gene\|7732A37D59E2643F232F2C0AFE51BCF7A79EDE29\|folE]	biosynthesis of folate and queuosine
[gene\|93380E8EEB672C14C9BE2B5A6D8573FBCA149514\|folEB]	biosynthesis of folate and queuosine
[gene\|D2B189C6292ACE1B25658B407C284E9A683EAE5B\|folK]	biosynthesis of folate
[gene\|956E33AAAADB302EB8663E4B75C917242D3AD2C0\|pabA]	biosynthesis of folate and tryptophan
[gene\|B189AD3E3D18876E1956763182D835A151727392\|pabB]	biosynthesis of folate
[gene\|865678B10097C40337F5EEA77FF0F6E7BF5358DC\|pabC]	biosynthesis of folate
[gene\|FA9539CB701BC47FD4E849FBA6D7B201B27C6104\|sul]	biosynthesis of folate

[category|SW.2.6.2.6|2.6.2.6. Biosynthesis of heme/ siroheme]

Name	Function
[gene\|B308BDECB15D68DF0EC2E49341DB5E7F9B3E14D1\|ctaA]	heme biosynthesis
[gene\|83F5D5FCCAFADB7231ACD9BE7941820240954C70\|ctaB]	heme biosynthesis
[gene\|6CE139563BBD7C1C97AEC3AA3F88146C4EEA79E4\|ctaO]	heme biosynthesis
[gene\|8BB8EECA8ECFA1CC6D46E81250905DBC6D2C503E\|gsaB]	biosynthesis of heme, modification of [protein\|3054CD45713BBD69C2A528DE24AF6AF37175FD9D\|efp]
[gene\|B1413EB525000744BE8E429E760220A13BC4530D\|hemA]	porphyrin biosynthesis
[gene\|70263A55987F110209367CF45AD65A584AD3077D\|hemB]	heme biosynthesis
[gene\|D266E22E07B849E2AEB0EF232C49A2FE1EA4E02B\|hemC]	heme biosynthesis
[gene\|33459D4389F85D60311FCE770BBA0ED9802BA342\|hemD]	heme biosynthesis
[gene\|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA\|hemE]	heme biosynthesis
[gene\|E4C588EC93132CCBE4F40559F8A480A66A2D82D7\|hemH]	biosynthesis of heme
[gene\|A54B2C86638D474F5F892003B42C535B5B39A42E\|hemL]	heme biosynthesis
[gene\|757C51296E198849EAC1FFA4D37121D9085930A8\|hemN]	heme biosynthesis
[gene\|51B3ED39FC423164A6FD6271815E029137B362A9\|hemQ]	biosynthesis of heme
[gene\|88616BA1E853E11BE0CB18F06287CA4C68143148\|hemX]	heme biosynthesis
[gene\|7541AD7D06BC4CE30AD576562E0053CC1E25B4D6\|hemY]	biosynthesis of heme
[gene\|5A1E474D2A6043ACF0DF00FEA7F66BFB1332C691\|hemZ]	heme biosynthesis
[gene\|9349C4646A56F933041EBE750F1BE86BAE7A60D9\|sirB]	siroheme biosynthesis, sulfite reduction
[gene\|92831D5A8E07A18BA6C6978123769D00D685BB45\|ylnD]	siroheme biosynthesis , sulfite reduction
[gene\|8BAB9B12D9D58A45446DC6CB7F48869089800FD3\|ylnF]	siroheme biosynthesis , sulfite reduction

[category|SW.2.6.2.7|2.6.2.7. Biosynthesis and scavenging of lipoic acid]

Name	Function
[gene\|58CF62EBA28E77668A0B5319142C8AC20D81CD8A\|gcvH]	glycine utilization
[gene\|2EC820F54911603A99444DC922E41C60AA526EB2\|lipA]	synthesis of lipoic acid
[gene\|F2E881F4BE0968C75BD75A5EFF4C7CA642034796\|lipL]	lipoic acid metabolism
[gene\|19CEB80CF637F1FED7C493EF743B4BFA632C8D44\|lipM]	biosynthesis of lipoic acid
[gene\|F68611DF326880FCCB4EE3C2B364ECCC3DEAD78D\|lplJ]	scavenging of lipoic acid

[category|SW.2.6.2.8|2.6.2.8. Biosynthesis of menaquinone]

Name	Function
[gene\|C45A5935559F0DAAD70F808725AF730BC18A2B0A\|hepS]	menaquinone biosynthesis
[gene\|3CAEA54E80A0B56EE120B881C8CDBE055AF6BDC1\|hepT]	menaquinone biosynthesis
[gene\|34DBBDD76A0B36867E5116FF17391DF70062F745\|menA]	biosynthesis of menaquinone
[gene\|224584953B0BC1AF666CD69372B2D53AC56F6752\|menB]	biosynthesis of menaquinone
[gene\|9B2F45BC37D4F356B366447A33DC95639EF484EE\|menC]	biosynthesis of menaquinone
[gene\|E3283812B7EB374EAC8722ECCE28432DE24B7B4C\|menD]	biosynthesis of menaquinone
[gene\|16412BAB04BBF9FD1C3653328923687874C81868\|menE]	biosynthesis of [metabolite\|menaquinone]
[gene\|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03\|menF]	biosynthesis of menaquinone
[gene\|DDD40AEBBCBD3C19661A72B85912E266DBF267B3\|menH]	biosynthesis of menaquinone

[category|SW.2.6.2.9|2.6.2.9. Biosynthesis of menaquinone/ based on similarity]

Name	Function
[gene\|74659B6794496912E139B3CF9EFF787B63729A3F\|ytxM]	ubiquinone and menaquinone biosynthesis

[category|SW.2.6.2.10|2.6.2.10. Biosynthesis of molybdopterin]

Name	Function
[gene\|19EB8E7CBC0E8D7A6429ADFFF93D1F71EFE3FF11\|moaA]	nitrate respiration
[gene\|E89A93C59339AB8814B92A2DF8C3FF95C5C940D3\|moaB]	nitrate respiration
[gene\|5C3EAEE1287FFB1541A31B31A8B6627E60A4D2EB\|moaD]	nitrate respiration
[gene\|12F27FA4DB8232B52271565C4F4937520A4F5C7B\|moaE]	nitrate respiration
[gene\|C6DB8499752ED1DBF276C0E46CC561450BED6A40\|mobA]	nitrate respiration
[gene\|A283C34375EDF495940E2F03C4FB6A9FE841FA1E\|mobB]	nitrate respiration
[gene\|03DBD906E31D6A8A4D14C9E2DACF0F1AB9F8DAA8\|moeA]	nitrate respiration
[gene\|C163CF34BAA3A37DCC67851DEE5889BB7AD208AB\|moeB]	nitrate respiration
[gene\|4A8D74B83E20FA138ED66F0D8FD456B69B740D92\|ydiG]	unknown

[category|SW.2.6.2.11|2.6.2.11. Biosynthesis of NAD(P)]

Name	Function
[gene\|F92F17578F06EF2292D0923662933463D7C86498\|nadA]	NAD biosynthesis
[gene\|D30D059185DFB828AB0FD07D600DBC3FD0973198\|nadB]	NAD biosynthesis
[gene\|1368734DCC28C618AA173B865784BDDAEA912623\|nadC]	NAD biosynthesis
[gene\|AA4BB1F5B58371D536A6BBA86F6ECB5E5BFB12A8\|nadD]	NAD biosynthesis
[gene\|4B74B1653D783779AFB37EDF9D33E7D6F1AC92B5\|nadE]	NAD biosynthesis
[gene\|2A2640A0501ECEA44A3C0C4842FAC053FB422A1F\|nadF]	generation of NADP from NAD
[gene\|510DE075EA964D22C42DEB171509F6CDA600A402\|nadR]	regulation of NAD biosynthesis
[gene\|0037A6808E75C2A2E207A7005EFDA71FCE90BAD8\|niaP]	uptake of niacin
[gene\|A6746AE1B92A0CDCCB22B57B6DF78094BB0223A8\|nifS]	NAD biosynthesis
[gene\|26430DCCEC263E7D03A3BBA4E7D636A250C3208B\|pncA]	NAD salvage
[gene\|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058\|pncB]	NAD salvage and biosynthesis
[gene\|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7\|ytdI]	generation of NADP from NAD

[category|SW.2.6.2.12|2.6.2.12. Biosynthesis of pyridoxal phosphate]

Name	Function
[gene\|FEDD589EA9982856730E809F21B7930F688FDC42\|pdxK]	biosynthesis of pyridoxal phosphate
[gene\|651D1E534490276B9BE7BFE7B5819176AE09891E\|pdxS]	pyridoxal-5-phosphate biosynthesis
[gene\|6F96C10759C1C20B3A6B396E3718F0A9281F100A\|pdxT]	pyridoxal-5-phosphate biosynthesis

[category|SW.2.6.2.13|2.6.2.13. Biosynthesis/ acquisition of cobalamine (B12))]

Name	Function
[gene\|468D9141EAC78556C9F6C564875F70EC43E60C1C\|yvqK]	unknown
[gene\|128EBAE9C14C7BB75173DF912853A6FCE86ABCE4\|yvrA]	uptake of [metabolite\|cobalamin]
[gene\|1DC4A3D7E93677B0EAD15F43C80E50FD98527EBC\|yvrB]	uptake of [metabolite\|cobalamin]
[gene\|C76265F521D9A153F28AC6BACD935CC20DEA5D9C\|yvrC]	uptake of [metabolite\|cobalamin]

important original publications

24972371,28504670,37301357,38965781,39686976

important reviews

11153271,22616866,19348578,18314013,14675553,10382260,24442413,21646432,21437340,26758294,31134210,36677456,39675885

Page visits:

Time of last update: 2024-12-18 11:20:21

Author of last update: Jstuelk

Name	Function
[gene\|151A61315ADAA7213502F15C0C0ED636A4C3EA7C\|aimA]	low affinity uptake of [metabolite\|serine], [metabolite\|glutamate], [metabolite\|asparagine], [metabolite\|glycine], [metabolite\|alanine], and [metabolite\|beta-alanine]
[gene\|219586A3F378DC38EA076FD39B99D41136BDE722\|alaP]	uptake of D- and L-alanine and of ß-alanine
[gene\|B3362449EF3C9D533090FBD7E7333A3CC5D902CB\|coaA]	biosynthesis of [metabolite\|coenzyme A]
[gene\|2B67C63442F28F6BCBA3BA6DE4B563C73E8DF16C\|coaBC]	biosynthesis of [metabolite\|coenzyme A]
[gene\|6DAAEF20B68139A732FDCDABD0C420A0C928D373\|coaD]	biosynthesis of [metabolite\|coenzyme A]
[gene\|E163A282560DB882B81E783E7E95E1960F4AE4D2\|coaE]	synthesis of [metabolite\|coenzyme A]
[gene\|9B8EAD4EDDA97526D4462F6F3205F81FECD039DE\|coaX]	biosynthesis of [metabolite\|coenzyme A]
[gene\|EC1CB2FD563EFDA391D13EB8ADFDC8C9734E9D57\|ilvC]	biosynthesis of branched-chain amino acids and [metabolite\|coenzyme A]
[gene\|A0001681244113B808757281C1B70C0C94F28A27\|panB]	biosynthesis of [metabolite\|coenzyme A]
[gene\|8BE55434677F4EC3D6766C7163496CB1B659F57F\|panC]	biosynthesis of [metabolite\|coenzyme A]
[gene\|EE712C1EC9E9C371847C83F7D75C189B276CD4B6\|panD]	biosynthesis of [metabolite\|coenzyme A]
[gene\|0F153803781C9AC8321FB14F926B645C45E53B00\|panE]	biosynthesis of [metabolite\|coenzyme A]
[gene\|60264E4BE76F5995A8317294D05FC27F8B34E09D\|panG]	biosynthesis of [metabolite\|coenzyme A]
[gene\|22215066A7BEA4E53189DE6639C19D1AD86DA7F4\|panU]	uptake of [metabolite\|pantothenate]

Name	Function
[gene\|468D9141EAC78556C9F6C564875F70EC43E60C1C\|yvqK]	unknown
[gene\|128EBAE9C14C7BB75173DF912853A6FCE86ABCE4\|yvrA]	uptake of [metabolite\|cobalamin]
[gene\|1DC4A3D7E93677B0EAD15F43C80E50FD98527EBC\|yvrB]	uptake of [metabolite\|cobalamin]
[gene\|C76265F521D9A153F28AC6BACD935CC20DEA5D9C\|yvrC]	uptake of [metabolite\|cobalamin]