RNA polymerase

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Parent categories	3. Information processing 3.2. RNA synthesis and degradation 3.2.1. Transcription
Neighbouring categories	Sigma factors
Related categories	protein-protein interactions transcription
Overview on the categories (Excel file) All genes and their categories (Excel file)

The enzyme responsible for transcription

As an important difference as compared to the E. coli enzyme, the B. subtilis RNA polymerase has a strong preference for G as first nucleotides in transcripts PubMed

Components of the RNA polymerase

Core subunits

RpoA: alpha subunit
RpoB: beta subunit
RpoC: beta' subunit

The stoichiometry of the enzyme is RpoA(2)-RpoB-RpoC

Sigma factors

In addition to the housekeeping sigma factor, SigA, there are several other sigma factors with different promoter recognition specifiity that are active under specific conditions (such as stress or sporulation)

Small accessory subunits

RpoE: delta subunit
RpoY: epsilon subunit
YloH: omega subunit

Other interaction partners

NusA: essential elongation factor
NusG: transcription elongation factor PubMed
GreA: resolves promoter proximal pausing of RNA polymerase PubMed
CshA: DEAD-box RNA helicase PubMed
PcrA: ATP-dependent DNA helicase PubMed

Temporary interaction partners

Spx: transcription regulator, interacts with RpoA
MgsR: transcription regulator orthologous to Spx, interacts with RpoA
Btr: transcription activator PubMed
YlyA: modulates SigG-dependent transcription PubMed

Additional interaction partners of the RNA polymerase (no specific subunit specified)
- HelD, TopA, CssR, RnhC, YpsC, Mfd, YpiA, YdjO, ResD PubMed

Back to protein-protein interactions

References

Reviews

The structure of RNA polymerase

Important original publications