UvrC

• Description: excinuclease ABC (subunit C)
  
  

Gene name	uvrC
Synonyms	uvrB
Essential	no
Product	excinuclease ABC (subunit C)
Function	DNA repair after UV damage
Gene expression levels in SubtiExpress: uvrC
Interactions involving this protein in SubtInteract: UvrC
MW, pI	69 kDa, 9.503
Gene length, protein length	1794 bp, 598 aa
Immediate neighbours	lysC, trxA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

• Locus tag: BSU28490

Database entries

• BsubCyc: BSU28490

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: uvrC family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • UvrB-UvrC PubMed

• Localization:

Database entries

• BsubCyc: BSU28490

• Structure: 3C65 (5' endonuclease domain, Geobacillus stearothermophilus)

• UniProt: P14951

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: uvrC PubMed

• Expression browser: uvrC PubMed

• Sigma factor:

• Regulation:
  • induced upon DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed]

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

<pubmed>16464004 15927210 7801120 22933559 </pubmed>

Original publications

<pubmed>2174442,2559145 ,16267290, </pubmed>