Revision as of 11:36, 11 June 2009

Description: RNA polymerase ECF-type sigma factor SigW

Gene name	sigW
Synonyms	ybbL
Essential	no
Product	RNA polymerase ECF-type sigma factor SigW
Function	resistance against SdpC that functions in detoxification and/or production of antimicrobial compounds
MW, pI	21 kDa, 8.614
Gene length, protein length	561 bp, 187 aa
Immediate neighbours	trnSL-Gln2, ybbM
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

Locus tag: BSU01730

Phenotypes of a mutant

Database entries

DBTBS entry: [1]

SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

Catalyzed reaction/ biological activity:

Protein family: ECF subfamily (according to Swiss-Prot)

Paralogous protein(s):

Genes controlled by SigW

abh, pbpE-racX,xpaC-yaaN, yteI, yuaG, yknXYZ, ydjP, yfhM

Extended information on the protein

Kinetic information:

Domains:

Modification:

Cofactor(s):

Effectors of protein activity:

Interactions: RsiW-SigW

Localization:

Database entries

Structure:

Swiss prot entry: Q45585

KEGG entry: [3]

E.C. number:

Additional information

Expression and regulation

Operon:

Sigma factor:

Regulation:
- repressed during logrithmic growth (AbrB) PubMed

Regulatory mechanism:
- AbrB: transcription repression PubMed
- AbrB: transcription repression PubMed

Additional information:

Biological materials

Mutant:

Expression vector:

lacZ fusion:

GFP fusion:

two-hybrid system:

Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Thomas Wiegert, University of Bayreuth, Germany Homepage

Your additional remarks

References

Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed

@@ Line 1: / Line 1: @@
-#REDIRECT [[RsiW]]
+* '''Description:''' RNA polymerase ECF-type [[sigma factor]] SigW <br/><br/>
+{| align="right" border="1" cellpadding="2"
+|-
+|style="background:#ABCDEF;" align="center"|'''Gene name'''
+|''sigW''
+|-
+|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ybbL ''
+|-
+|style="background:#ABCDEF;" align="center"| '''Essential''' || no
+|-
+|style="background:#ABCDEF;" align="center"| '''Product''' || RNA polymerase ECF-type [[sigma factor]] SigW
+|-
+|style="background:#ABCDEF;" align="center"|'''Function''' || resistance against SdpC <br/>that functions in detoxification and/or <br/>production of antimicrobial compounds
+|-
+|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 21 kDa, 8.614
+|-
+|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 561 bp, 187 aa
+|-
+|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[trnSL-Gln2]]'', ''[[ybbM]]''
+|-
+|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB11949&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
+|-
+|colspan="2" | '''Genetic context''' <br/> [[Image:sigW_context.gif]]
+ <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
+|-
+|}
+__TOC__
+<br/><br/><br/><br/>
+=The gene=
+=== Basic information ===
+* '''Locus tag:''' BSU01730
+===Phenotypes of a mutant ===
+=== Database entries ===
+* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sigW-ybbM.html]
+* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11573]
+=== Additional information===
+=The protein=
+=== Basic information/ Evolution ===
+* '''Catalyzed reaction/ biological activity:'''
+* '''Protein family:''' ECF subfamily (according to Swiss-Prot)
+* '''Paralogous protein(s):'''
+=== Genes controlled by SigW ===
+''[[abh]]'', ''[[pbpE]]-[[racX]]'',''[[xpaC]]-[[yaaN]]'', ''[[yteI]], [[yuaG]], [[yknX| yknXYZ]], [[ydjP]], [[yfhM]]''
+=== Extended information on the protein ===
+* '''Kinetic information:'''
+* '''Domains:'''
+* '''Modification:'''
+* '''Cofactor(s):'''
+* '''Effectors of protein activity:'''
+* '''Interactions:''' [[RsiW]]-[[SigW]]
+* '''Localization:'''
+=== Database entries ===
+* '''Structure:'''
+* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/Q45585 Q45585]
+* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU01730]
+* '''E.C. number:'''
+=== Additional information===
+=Expression and regulation=
+* '''Operon:'''
+* '''[[Sigma factor]]:'''
+* '''Regulation:'''
+** repressed during logrithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12076816 PubMed]
+* '''Regulatory mechanism:'''
+** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12076816 PubMed]
+** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12076816 PubMed]
+* '''Additional information:'''
+=Biological materials =
+* '''Mutant:'''
+* '''Expression vector:'''
+* '''lacZ fusion:'''
+* '''GFP fusion:'''
+* '''two-hybrid system:'''
+* '''Antibody:'''
+=Labs working on this gene/protein=
+[[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]
+[[Thomas Wiegert]], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas%20Wiegert-Dateien/Thomas%20Wiegert.html Homepage]
+=Your additional remarks=
+=References=
+# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]