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| * '''Description:''' ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of [[sporulation]] initiation <br/><br/>
| | {{#bank: ParA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''parA''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''soj, spo0JA ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || negative regulator of [[sporulation]] initiation
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || forespore chromosome partitioning /<br/> negative regulation of [[sporulation]] initiation
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU40970 parA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ParA ParA]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 27 kDa, 4.903
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 759 bp, 253 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[parB]]'', ''[[yyaB]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU40970 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU40970 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU40970 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:soj_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=parA_4206397_4207158_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:soj_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU40970]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA condensation/ segregation]]}},
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| {{SubtiWiki category|[[sporulation/ other]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Spo0A regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU40970
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU40970&redirect=T BSU40970]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/soj-spo0J.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10055]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' regulates [[DNA replication]] initiation by either inhibiting or activating the [[DNA replication]] initiator protein [[DnaA]] {{PubMed|21235642}}; regulation of ''Spo0A'' expression {{PubMed|10852876}}
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| * '''Protein family:''' parA family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| ** [[ParB]] inhibits [[ParA]] dimerization and concomitant DNA-binding activity by stimulating [[ParA]] ATPase activity {{PubMed|21235642}}
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[ParA]]-[[ParB]] {{PubMed|21235642}}
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| ** [[ParA]]-[[DnaA]] {{PubMed|22286949}}
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| * '''[[Localization]]:'''
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| ** polar/ septal at the cell membrane {{PubMed|20566861}}
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| ** polar localization depends on the proton motive force {{PubMed|20566861}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU40970&redirect=T BSU40970]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P37522 P37522]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU40970]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[parA]]-[[parB]]'' {{PubMed|22383849}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=parA_4206397_4207158_-1 parA] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
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| * '''Additional information:'''
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 84 {{PubMed|24696501}}
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 280 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| * [[Heath Murray]], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 20157337 22934648 </pubmed>
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| == Original publications ==
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| <pubmed>15659156,11532141,19450516,18854156,10619015,8866474,12492861,9701805,12950914,14651647, 19450516 20566861 21235642 10852876 14563866 26253537 22286949 21911367</pubmed>
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| [[Category:Protein-coding genes]]
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