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| * '''Description:''' subunit of DNA topoisomerase IV <br/><br/>
| | {{#bank: ParC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''parC''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''grlA ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| |style="background:#ABCDEF;" align="center"| '''Product''' || subunit of DNA topoisomerase IV
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| |style="background:#ABCDEF;" align="center"|'''Function''' || chromosome segregation and compaction
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU18100 parC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 91 kDa, 6.307
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2418 bp, 806 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[parE]]'', ''[[ynfC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU18100 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU18100 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU18100 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:parC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=parC_1935448_1937868_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:parC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU18100]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA condensation/ segregation]]}},
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| {{SubtiWiki category|[[essential genes]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[LexA regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU18100
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| ===Phenotypes of a mutant ===
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| essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU18100&redirect=T BSU18100]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/parEC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11803]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' topoisomerase gyrA/parC subunit family (according to Swiss-Prot)
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| * '''Paralogous protein(s):''' [[GyrA]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** cytoplasm (Homogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
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| ** polar localization in actively growing cells [http://www.ncbi.nlm.nih.gov/sites/entrez/9539793 PubMed]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU18100&redirect=T BSU18100]
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1WP5 1WP5] (C-terminal domain, Geobacillus stearothermophilus)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/Q45066 Q45066]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU18100]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[parE]]-[[parC]]'' {{PubMed|16267290}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=parC_1935448_1937868_1 parC] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| ** induced by DNA damage ([[LexA]]) {{PubMed|16267290}}
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| * '''Regulatory mechanism:'''
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| ** [[LexA]]: transcription repression {{PubMed|16267290}}
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| * '''Additional information:'''
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 67 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>16272394,15466871,,16267290,16479537 9539793</pubmed>
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| [[Category:Protein-coding genes]]
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