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| * '''Description:''' transcriptional repressor ([[GntR family]]) of the ''[[gamA]]-[[gamP]]'' operon <br/><br/>
| | {{#bank: GamR}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''gamR''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ybgA ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional regulator ([[GntR family]])
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of glucosamine utilization
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU02370 gamR]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 5.559
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 705 bp, 235 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[gamA]]'', ''[[ybgB]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU02370 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU02370 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU02370 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ybgA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ybgA_257791_258498_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ybgA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU02370]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell wall degradation/ turnover]]}},
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| {{SubtiWiki category|[[utilization of specific carbon sources]]}},
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| {{SubtiWiki category|[[transcription factors and their control]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[GamR regulon]]}}
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| = The [[GamR regulon]]: =
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| * ''[[gamA]]-[[gamP]]'', ''[[gamR]]-[[ybgB]]''
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU02370
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12747]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' [[GntR family]] of transcription factors
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| ** glucosamine-6-phosphate acts as molecular inducer that prevents GamR from binding to its operator sites in the promoter regions of the ''[[gamA]]-[[gamP]]'' and ''[[gamR]]-[[ybgB]]'' operons {{PubMed|24673833}}
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O31459 O31459]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU02370]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[gamR]]-[[ybgB]]'' {{PubMed|23667565}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ybgA_257791_258498_1 gamR] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|23667565}}
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| * '''Regulation:'''
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| ** induced by glucosamine ([[GamR]]) {{PubMed|24673833,23667565}}
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| * '''Regulatory mechanism:'''
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| ** [[GamR]]: transcription repression {{PubMed|24673833,23667565}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed> 10627040 23667565 24673833 </pubmed>
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| [[Category:Protein-coding genes]]
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