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| * '''Description:''' Sec-independent membrane protein translocase, required for development of [[genetic competence]]<br/><br/>
| | {{#bank: YidC2}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''yidC2''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqjG, oxaAB ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || Sec-independent membrane protein translocase
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || membrane insertion of proteins and [[protein secretion]]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 9.903
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 825 bp, 275 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[mifM]]'', ''[[yqjF]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU23890 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU23890 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU23890 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yqjG_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=oxaAB_2483904_2484731_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:yqjG_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU23890]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[protein secretion]]}},
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| {{SubtiWiki category|[[genetic competence]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[MifM regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU23890
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU23890&redirect=T BSU23890]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqjG.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11736]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' YidC/Oxa1/Alb3 family {{PubMed|20800571,21194367,15802250}}
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| * '''Paralogous protein(s):''' [[SpoIIIJ]], one of the two proteins has to be present for viability [http://www.ncbi.nlm.nih.gov/sites/entrez/17114254 PubMed]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** membrane {{PubMed|22864117}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU23890&redirect=T BSU23890]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P54544 P54544]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU23890]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[mifM]]-[[yidC2]]'' {{PubMed|22383849}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=oxaAB_2483904_2484731_1 yidC2] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** repressed by large amounts of [[SpoIIIJ]], induced by small amounts of [[SpoIIIJ]] ([[MifM]]) {{PubMed|19779460}}
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| * '''Regulatory mechanism:'''
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| ** [[MifM]]: "attenuation mechanism", an mRNA hairpin of the ''yqjG'' transcript unfold upon translation arrest of [[MifM]] at decreased [[SpoIIIJ]] levels {{PubMed|19779460}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>22688815 20800571,21194367,15802250 25947384</pubmed>
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| == Original publications ==
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| <pubmed>17114254, 15995216, 11889108, 12586834 19717609 19779460 21204254 22383849 22864117 24443530 25313395 25359772 25855636 25903689</pubmed>
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| [[Category:Protein-coding genes]]
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