OppC

• Description: oligopeptide ABC transporter (permease)
  
  

Gene name	oppC
Synonyms	spo0KC
Essential	no
Product	oligopeptide ABC transporter (permease)
Function	initiation of sporulation, competence development
Gene expression levels in SubtiExpress: oppC
Interactions involving this protein in SubtInteract: OppC
Metabolic function and regulation of this protein in SubtiPathways: oppC
MW, pI	33 kDa, 10.107
Gene length, protein length	915 bp, 305 aa
Immediate neighbours	oppB, oppD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, utilization of nitrogen sources other than amino acids, genetic competence, phosphorelay, membrane proteins

This gene is a member of the following regulons

CodY regulon, ScoC regulon, TnrA regulon

The gene

Basic information

• Locus tag: BSU11450

Database entries

• BsubCyc: BSU11450

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • required for the uptake of quorum sensing peptides such as PhrH PubMed

• Protein family: ABC transmembrane type-1 domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (OppD-OppF)-(OppB-OppC)-OppA PubMed

• Localization: cell membrane PubMed

Database entries

• BsubCyc: BSU11450

• Structure:

• UniProt: P24139

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: oppA-oppB-oppC-oppD-oppF PubMed

• Expression browser: oppC PubMed

• Sigma factor:

• Regulation:
  • expressed in the absence of good nitrogen sources (glutamine or ammonium) (TnrA) PubMed
  • repressed during exponential growth (ScoC) PubMed

• Regulatory mechanism:
  • TnrA: transcription activation PubMed
  • ScoC: transcription repression PubMed
  • CodY: transcription repression, no derepression occurs, however, in a codY mutant, due to increased repression by ScoC PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 145 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 1155 PubMed

Biological materials

• Mutant:
  • BP68 (spc) available in Fabian Commichau's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>12823818,1901616,10092453,9252573,21908671,12823818,10383984, 7997159 25966844 1899858</pubmed>