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| * '''Description:''' spore coat protein (inner) <br/><br/>
| | {{#bank: CotD}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''cotD''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || spore coat protein (inner)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || resistance of the spore
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU22200 cotD]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 8 kDa, 7.373
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 225 bp, 75 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypsA]]'', ''[[yprB]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU22200 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU22200 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU22200 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:cotD_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=cotD_2332784_2333011_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:cotD_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU22200]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[sporulation proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[GerE regulon]]}},
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| {{SubtiWiki regulon|[[SigK regulon]]}},
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| {{SubtiWiki regulon|[[SpoIIID regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU22200
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU22200&redirect=T BSU22200]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/cotD.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10493]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' nhaC Na(+)/H(+) antiporter family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** inner spore coat {{PubMed|19933362}}, localization depends on [[SafA]] {{PubMed|22171814}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU22200&redirect=T BSU22200]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P07791 P07791]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU22200]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''cotD'' (according to [http://dbtbs.hgc.jp/COG/prom/cotD.html DBTBS])
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=cotD_2332784_2333011_-1 cotD] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigK]] {{PubMed|15699190}}
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| * '''Regulation:'''
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| ** expressed late during sporulation in the mother cell ([[SigK]], [[SpoIIID]], [[GerE]]) {{PubMed|15383836,15699190,7966271}}
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| * '''Regulatory mechanism:'''
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| ** [[SpoIIID]]: transcription repression {{PubMed|7966271}}
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| ** [[GerE]]: transcription activation {{PubMed|15383836}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1S104 ( ''cotD''::''cat''), {{PubMed|2821284}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S104&Search=1S104 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| == Reviews ==
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| <pubmed>23202530</pubmed>
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| == Original publications ==
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| <pubmed> 19933362,1518043,2821284,2492118,1691789,14651647, 15699190,7966271 22171814 15383836</pubmed>
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| [[Category:Protein-coding genes]]
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