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| * '''Description:''' [[RNA polymerase]] sporulation forespore-specific (late) [[sigma factor]] SigG <br/><br/>
| | {{#bank: SigG}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''sigG''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''spoIIIG ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[RNA polymerase]] sporulation forespore-specific <br/>(late) [[sigma factor]] SigG
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[transcription]] of sporulation genes (late forespore)
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15330 sigG]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=SigG SigG]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.496
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 780 bp, 260 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sigE]]'', ''[[ylmA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU15330 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU15330 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU15330 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:sigG_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sigG_1605630_1606412_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:sigG_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15330]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[transcription]]}},
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| {{SubtiWiki category|[[sigma factors and their control]]}},
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| {{SubtiWiki category|[[sporulation proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[AbrB regulon]]}},
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| {{SubtiWiki regulon|[[SigF regulon]]}},
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| {{SubtiWiki regulon|[[SigG regulon]]}},
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| {{SubtiWiki regulon|[[SinR regulon]]}},
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| {{SubtiWiki regulon|[[Spo0A regulon]]}}
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|
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| =The [[SigG regulon]]=
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU15330
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15330&redirect=T BSU15330]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/spoIIGA-sigE-sigG.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10236]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' sigma-70 factor family (according to Swiss-Prot)
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| * '''Paralogous protein(s):''' [[SigF]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| ** [[Gin]] inhibits SigG activity [http://www.ncbi.nlm.nih.gov/sites/entrez/19497328 PubMed]
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| ** the activity of [[SigG]]-containing [[RNA polymerase]] is modulated by [[YlyA]] {{PubMed|23678950}}
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[SigG]]-[[RpoB]]-[[RpoC]]
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| ** [[CsfB]]-[[SigG]] {{PubMed|25835496,19497328}}
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| ** [[SpoIIAB]]-[[SigG]] {{PubMed|8885263}}
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15330&redirect=T BSU15330]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P19940 P19940]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU15330]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[spoIIGA]]-[[sigE]]-[[sigG]]'' {{PubMed|1902213}}
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| ** ''[[sigG]]'' {{PubMed|1902213}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sigG_1605630_1606412_1 sigG] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| ** ''[[spoIIGA]]'': [[SigA]] {{PubMed|2512576}}
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| ** ''[[sigG]]'': [[SigF]], [[SigG]] {{PubMed|1902213}}
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| * '''Regulation:'''
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| ** ''[[spoIIGA]]'': expressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8288522,15687200 PubMed]
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| ** ''[[sigG]]'': expressed during sporulation ([[SigF]], [[SigG]]) {{PubMed|1902213}}
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| ** the mRNA accumulates in a ''[[ymdB]]'' mutant {{PubMed|24163345}}
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| * '''Regulatory mechanism:'''
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| ** repression by [[SinR]]
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| ** [[Spo0A]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8288522,15687200 PubMed]
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| ** [[AbrB]]: transcription repression {{PubMed|20817675}}
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| * '''Additional information:'''
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| ** the mRNA half-life is about 2.6 min {{PubMed|24163345}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[Charles Moran]], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>20833318 </pubmed>
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| ==The [[SigG regulon]]==
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| <pubmed>16497325</pubmed>
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| ==Original Publications==
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| <pubmed>1900507,1902463,15175314,10806362,1902213,2497051,12867473,16707705,9829949,1487728,2448286, 9852018,19497328,8126438,8355618, 24163345 18820020,2493633, 7961403,15256570,12813085,9004507, 8885263, 18485064,19390092 23678950 22984259, 20817675,21935351 </pubmed>
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| [[Category:Protein-coding genes]]
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