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| * '''Description:''' excinuclease ABC (subunit B) <br/><br/>
| | {{#bank: UvrB}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''uvrB''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dinA, uvrA ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || excinuclease ABC (subunit B)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair after UV damage
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35170 uvrB]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=UvrB UvrB]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 76 kDa, 5.26
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1983 bp, 661 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[uvrA]]'', ''[[csbA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35170 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35170 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35170 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:uvrB_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=uvrB_3612945_3614930_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:uvrB_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35170]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA repair/ recombination]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[LexA regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU35170
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35170&redirect=T BSU35170]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/uvrBA.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10502]
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| === Additional information===
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| * A mutation was found in this gene after evolution under relaxed selection for sporulation {{PubMed|21821766}}
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' uvrB family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[UvrA]]-[[UvrB]] {{PubMed|16464004}}
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| ** [[UvrB]]-[[UvrC]] {{PubMed|16464004}}
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| ** [[UvrB]] interacts sequentially with [[UvrA]] and [[UvrC]], a complex of the three proteins was never observed {{PubMed|16464004}}
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| ** [[UvrB]]-[[PcrA]] {{PubMed|24147116}}
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| * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35170&redirect=T BSU35170]
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2NMV 2NMV] (bound to fluorescein-adducted DNA); [http://www.rcsb.org/pdb/explore.do?structureId=2D7D 2D7D] ternary complex involving UvrB* (a C-terminal truncation of full-length UvrB), a polythymine trinucleotide and ADP {{PubMed|16426634}}
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P37954 P37954]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU35170]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[uvrB]]-[[uvrA]]'' (according to [http://dbtbs.hgc.jp/COG/prom/uvrBA.html DBTBS])
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=uvrB_3612945_3614930_-1 uvrB] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** induced upon DNA damage ([[LexA]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8226626 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[LexA]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8226626 PubMed]
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:''' GP1175 (del ''uvrAB''::''ermC'') (available in the [[Stülke]] lab)
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>16464004 15927210 7801120 22933559 </pubmed>
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| == Original publications ==
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| <pubmed>8226626, 9555905 16426634 21821766 24147116 21145481 </pubmed>
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| [[Category:Protein-coding genes]]
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