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| * '''Description:''' RNA component of [[RNase]] P <br/><br/>
| | {{#bank: RnpB}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''rnpB''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''rnaP ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes {{PubMed|23109554}}
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| |style="background:#ABCDEF;" align="center"| '''Product''' || RNA component of ribonuclease P <br/>([[RNase]] P) (catalytic subunit, ribozyme)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || cleavage of precursor sequences <br/>from the 5' ends of pre-tRNAs
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this RNA in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=RnpB RnpB]
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| |style="background:#ABCDEF;" align="center"| '''Gene length''' || 401 bp
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypsC]]'', ''[[ypsB]]''
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/rnpB_nucleotide.txt Gene sequence (+200bp) ]'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:rnpB_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/><br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[Rnases]]}},
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| {{SubtiWiki category|[[translation]]}},
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| {{SubtiWiki category|[[ncRNA]]}},
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| {{SubtiWiki category|[[essential genes]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:'''
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| ===Phenotypes of a mutant ===
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| * essential {{PubMed|23109554}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU_MISC_RNA_35&redirect=T BSU_misc_RNA_35]
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG00045]
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| * '''Structure:'''
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| ** [http://www.rcsb.org/pdb/explore.do?structureId=2A64 2A64] (from ''Geobacillus stearothermophilus'')
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| ** [http://www.rcsb.org/pdb/explore.do?structureId=1NBS 1NBS] (specificity domain)
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| ** [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3OKB 3OKB] (complex of [[RnpA]] with the RNA [[RnpB]] and tRNA, from ''Thermotoga maritima'') {{PubMed|21076397}}
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| =The RNA=
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| * '''Biological activity:''' 5' end maturation of precursor tRNAs
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| * '''RNA family:'''
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| * '''cofactor:''' divalent cations (Ca(II) or Mg (II)) for the stabilization of the complex with pre-tRNA {{PubMed|20434461}}
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| * '''[[Interactions]]:''' [[RnpA]]-[[RnpB]] {{PubMed|21622899}}
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/RNA=
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| * [[Carol Fierke]], University of Michigan, Ann Arbor, USA [https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=fierke homepage]
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| * [[Roland Hartmann]], Marburg University, Germany [http://www.pharmazie.uni-marburg.de/pharmchem/akhartmann/ag_hartmann.htm homepage]
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 19215776 17868095 14691942 16650980 16980936 16679018 14550630 </pubmed>
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| ==Original Publications==
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| <pubmed>16470227,17355991,11812129,10390342,11454206, 19549719,11454206, 19717440 ,20133747 19932118 20188108 20434461 17299131 14510496 12951523 12836338 11577704 20557101 25352137 23109554,21076397,21622899</pubmed>
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| [[Category:small RNA]]
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