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| * '''Description:''' thiol-disulfide oxidoreductase <br/><br/>
| | {{#bank: BdbB}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''bdbB''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yolK ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || thiol-disulfide oxidoreductase
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || oxidative folding of proteins
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21440 bdbB]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=BdbB BdbB]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 9.415
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 444 bp, 148 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[bhlB]]'', ''[[sunS]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU21440 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU21440 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU21440 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:bdbB_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbB_2265225_2265671_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:bdbB_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21440]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[chaperones/ protein folding]]}},
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| {{SubtiWiki category|[[SP-beta prophage]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Abh regulon]]}},
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| {{SubtiWiki regulon|[[AbrB regulon]]}},
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| {{SubtiWiki regulon|[[Rok regulon]]}},
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| {{SubtiWiki regulon|[[YvrHb regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU21440
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU21440&redirect=T BSU21440]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sunT-bdbA-yolJ-bdbB.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13587]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** oxidative folding of [[SunA]] (together with [[BdbC]])
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| * '''Protein family:''' NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU21440&redirect=T BSU21440]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P68571 P68571]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU21440]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| ** '''Operon:''' ''[[sunT]]-[[bdbA]]-[[sunS]]-[[bdbB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbB_2265225_2265671_-1 bdbB] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** repressed by [[Rok]] [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed]
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| * '''Regulatory mechanism:'''
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| ** activated by [[YvrHb]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
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| ** [[Rok]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed]
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| ** [[AbrB]]: transcription repression{{PubMed|20817675}}
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| ** [[Abh]]: transcription activation {{PubMed|20817675}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>11872755 15743949,20817675 </pubmed>
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| [[Category:Protein-coding genes]]
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