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| * '''Description:''' lactate permease <br/><br/>
| | {{#bank: LutP}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''lutP''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvfH ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || lactate permease
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| |style="background:#ABCDEF;" align="center"|'''Function''' || lactate uptake
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU34190 lutP]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=lutP lutP]'''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 59 kDa, 9.476
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1689 bp, 563 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[lutR]]'', ''[[sigL]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU34190 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU34190 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU34190 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yvfH_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yvfH_3510780_3512471_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:lutP_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU34190]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[transporters/ other]]}},
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| {{SubtiWiki category|[[utilization of specific carbon sources]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[ComA regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU34190
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| ===Phenotypes of a mutant ===
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| poor growth with lactate as single carbon source [http://www.ncbi.nlm.nih.gov/sites/entrez/19201793 PubMed]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU34190&redirect=T BSU34190]
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11875]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' lactate uptake [http://www.ncbi.nlm.nih.gov/sites/entrez/19201793 PubMed]
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| * '''Protein family:''' lactate permease family (according to Swiss-Prot)
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| * '''Paralogous protein(s):''' [[LctP]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU34190&redirect=T BSU34190]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P71067 P71067]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU34190]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yvfH_3510780_3512471_1 lutP] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|25031425}}
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| * '''Regulation:'''
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| ** expressed at high cell density ([[ComA]]) {{PubMed|16091051}}
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| * '''Regulatory mechanism:'''
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| ** [[ComA]]: transcription activation ([[ComA]]) {{PubMed|16091051}}
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| * '''Additional information:'''
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 743 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[Richard Losick]], Harvard Univ., Cambridge, USA [http://www.mcb.harvard.edu/Losick/ homepage]
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| =Your additional remarks=
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| =References=
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| <pubmed> 19201793, 18763711 16091051 25031425 </pubmed>
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| [[Category:Protein-coding genes]]
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