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| * '''Description:''' [[two-component systems|two-component]] response regulator, control of cellular responses to protein secretion stress <br/><br/>
| | {{#bank: CssR}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''cssR''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvqA ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] response regulator
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| |style="background:#ABCDEF;" align="center"|'''Function''' || control of cellular responses to protein secretion stress
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33010 cssR]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=CssR CssR]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=cssR cssR]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 5.071
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 675 bp, 225 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[htrB]]'', ''[[cssS]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33010 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33010 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33010 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:cssR_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=cssR_3385724_3386401_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:cssR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33010]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[transcription factors and their control]]}},
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| {{SubtiWiki category|[[heat shock proteins]]}},
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| {{SubtiWiki category|[[phosphoproteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CssR regulon]]}}
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| =The [[CssR regulon]]:=
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| * ''[[cssR]]-[[cssS]]'', ''[[htrA]]'', ''[[htrB]]''
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU33010
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33010&redirect=T BSU33010]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/cssRS.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14131]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' OmpR family of two-component response regulators
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:''' phosphorylated by [[CssS]] on an Asp residue
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:''' phosphorylation likely affects DNA-binding activity
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[CssR]] interacts with the [[RNA polymerase]] {{PubMed|21710567}}
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| ** [[CssS]]-[[CssR]]
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| * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33010&redirect=T BSU33010]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O32192 O32192]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33010]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[cssR]]-[[cssS]]'' {{PubMed|11555295}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=cssR_3385724_3386401_1 cssR] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|12270824}}
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| * '''Regulation:'''
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| ** expressed under conditions of secretion stress ([[CssR]]) {{PubMed|12270824}}
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| * '''Regulatory mechanism:'''
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| ** [[CssR]]: transcription activation {{PubMed|12270824}}
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| * '''Additional information:'''
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 87 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>10094672,17600057,21710567,17088376,12270824,12270824 11555295, 19820159 21602801 21624103</pubmed>
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| [[Category:Protein-coding genes]]
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