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| * '''Description:''' probable DNA repair protein <br/><br/>
| | {{#bank: RadC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''radC''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ysxA ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || probable DNA repair protein
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| |style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28040 radC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 7.829
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 693 bp, 231 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[mreB]]'', ''[[maf]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU28040 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU28040 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU28040 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:radC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=radC_2861840_2862535_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:radC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28040]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA repair/ recombination]]}},
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| {{SubtiWiki category|[[genetic competence]]}},
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| {{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}},
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| {{SubtiWiki category|[[phosphoproteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[ComK regulon]]}},
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| {{SubtiWiki regulon|[[SigM regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU28040
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28040&redirect=T BSU28040]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/radC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10325]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' radC family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| ** phosphorylated on Arg-59 {{PubMed|22517742}}
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:''' Cytoplasm (Homogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28040&redirect=T BSU28040]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/Q02170 Q02170]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU28040]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''radC'' (according to [http://dbtbs.hgc.jp/COG/prom/radC.html DBTBS]), ''[[radC]]-[[mreB]]-[[mreC]]-[[mreD]]-[[minC]]-[[minD]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=radC_2861840_2862535_-1 radC] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigM]] {{PubMed|12775685}}
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| * '''Regulation:'''
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| ** expressed in response to cell wall antibiotics, ethanol, heat, acid, and superoxide stress ([[SigM]]) {{PubMed|12775685}}
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| ** expression is reduced in a [[SigV]] mutant {{PubMed|21926231}}
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| * '''Regulatory mechanism:'''
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| ** [[ComK]]: transcription activation {{PubMed|11948146,11918817}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| The ''radC'' locus is the chromosomal integration site for the φ105 prophage [http://www.ncbi.nlm.nih.gov/pubmed/24009114 Pubmed]
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| =References=
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| '''Additional publications:''' {{PubMed|21926231}}
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| <pubmed>17434969, 11948146,11918817,16479537 12775685 18179421 22517742</pubmed>
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| [[Category:Protein-coding genes]]
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