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| * '''Description:''' lichenan-specific [[PTS|phosphotransferase system]], EIIA component of the [[PTS]]<br/><br/>
| | {{#bank: LicA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''licA''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''celC ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || lichenan-specific [[PTS|phosphotransferase system]], <br/>EIIA component
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| |style="background:#ABCDEF;" align="center"|'''Function''' || lichenan uptake and phosphorylation
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38570 licA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=LicA LicA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=licA licA]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 4.641
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 330 bp, 110 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[licH]]'', ''[[licC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38570 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38570 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38570 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:licA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=licA_3959841_3960173_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:licA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38570]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[phosphotransferase systems]]}},
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| {{SubtiWiki category|[[utilization of specific carbon sources]]}},
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| {{SubtiWiki category|[[phosphoproteins]]}},
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| {{SubtiWiki category|[[Sporulation#Sporulation_proteins/_other|sporulation proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CcpA regulon]]}},
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| {{SubtiWiki regulon|[[LicR regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU38570
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU38570&redirect=T BSU38570]
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11349]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
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| * '''Protein family:''' [[PTS]] permease, lactose permease (Lac) family [http://www.ncbi.nlm.nih.gov/pubmed/10627040 PubMed]
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[LicA]]-[[PtsH|HPr]], [[LicA]]-[[LicB]]
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| * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU38570&redirect=T BSU38570]
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| * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3K1S 3K1S] (IIA(Cel) from ''B. anthracis'', 42% identity)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P46319 P46319]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU38570]
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| * '''E.C. number:''' 2.7.1.69
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[licB]]-[[licC]]-[[licA]]-[[licH]]'' {{PubMed|8990303}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=licA_3959841_3960173_-1 licA] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|8990303}}
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| * '''Regulation:'''
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| ** carbon catabolite repression ([[CcpA]]) {{PubMed|8990303}}
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| ** induction by oligomeric ß-glucosides ([[LicR]]){{PubMed|8990303}}
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| * '''Regulatory mechanism:'''
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| ** [[CcpA]]: transcription repression {{PubMed|8990303}}
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| ** [[LicR]]: transcription activation {{PubMed|8990303}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>19087206,8990303,16872404,,10438772,10627040 8990303, </pubmed>
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| [[Category:Protein-coding genes]]
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