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| * '''Description:''' uracil phosphoribosyltransferase <br/><br/>
| | {{#bank: Upp}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''upp''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ipc-35d ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || uracil phosphoribosyltransferase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || UMP synthesis
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU36890 upp]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=upp upp]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 22 kDa, 5.863
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 627 bp, 209 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[atpI]]'', ''[[glyA]]''
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/upp_nucleotide.txt Gene sequence (+200bp) ]'''
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/upp_protein.txt Protein sequence]'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:upp_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=upp_3788426_3789055_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:upp_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU36890]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU36890
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU36890&redirect=T BSU36890]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/upp.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10945]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
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| * '''Protein family:''' UPRTase family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU36890&redirect=T BSU36890]
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| * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2EHJ 2EHJ] (from ''Escherichia coli'', 52% identity, 73% similarity)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P39149 P39149]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU36890]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/2.4.2.9 2.4.2.9]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''upp'' {{PubMed|9353933}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=upp_3788426_3789055_-1 upp] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 2454 {{PubMed|24696501}}
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 6640 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1A832 (no resistance), {{PubMed|12366828}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A832&Search=1A832 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>,7798145, </pubmed>
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| [[Category:Protein-coding genes]]
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